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Publication : proceedings of the national academy of sciences of the united states of america
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Academic Journal

Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery

Subjects: Medicin och hälsovetenskap

  • Source: Proceedings of the National Academy of Sciences of the United States of America. 114(30):E6231-E6239

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Screen 'play' for drug discovery

Subjects: Multidisciplinary; Drug Discovery; High-Throughput Screening Assays

  • Source: Proceedings of the National Academy of Sciences of the United States of America. 119(45)

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SAR by kinetics for drug discovery in protein misfolding diseases

Subjects: 0301 basic medicine; Rhodanine; Amyloid beta

  • Source: Proceedings of the National Academy of Sciences of the United States of America

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Inner Workings: Zebrafish assay forges new approach to drug discovery

Subjects: Inner Workings; Drug Discovery; Models, Animal

  • Source: Proceedings of the National Academy of Sciences of the United States of America. 115(21)

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Academic Journal

DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor

Subjects: Genetics; Biotechnology; Breast Cancer

  • Source: Proceedings of the National Academy of Sciences of the United States of America. 119(6)

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Academic Journal

Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2

Subjects: Theory Of Computation; Biochemistry and Cell Biology; Biological Sciences

  • Source: Proceedings of the National Academy of Sciences of the United States of America. 120(2)

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Academic Journal

A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells

Subjects: Biological Sciences; Medicinal and Biomolecular Chemistry; Chemical Sciences

  • Source: Proceedings of the National Academy of Sciences of the United States of America. 118(43)

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Academic Journal

DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 Mpro inhibitors

Subjects: Medicinal and Biomolecular Chemistry; Chemical Sciences; Coronaviruses

  • Source: Proceedings of the National Academy of Sciences of the United States of America. 118(36)

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Academic Journal

Small molecule C381 targets the lysosome to reduce inflammation and ameliorate disease in models of neurodegeneration

Subjects: Neurosciences; Neurodegenerative; Development of treatments and therapeutic interventions

  • Source: Proceedings of the National Academy of Sciences of the United States of America. 119(11)

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Academic Journal

Discovery and characterization of bromodomain 2–specific inhibitors of BRDT

Subjects: Biochemistry and Cell Biology; Biomedical and Clinical Sciences; Medicinal and Biomolecular Chemistry

  • Source: Proceedings of the National Academy of Sciences of the United States of America. 118(9)

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  • 1-10 of  163 results for ""Drug discovery""