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Academic Journal

Development of a human liver microphysiological coculture system for higher throughput chemical safety assessment.

Authors : Ip, Blanche C^1,2 (AUTHOR) ; Madnick, Samantha J^1,2 (AUTHOR); Zheng, Sophia¹ (AUTHOR)

Subjects: *Microphysiological systems; *Chemical safety; *Multidrug resistance-associated proteins

Source: Toxicological Sciences. Jun2024, Vol. 199 Issue 2, p227-245. 19p.

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Academic Journal

Prenatal prednisone exposure impacts liver development and function in fetal mice and its characteristics.

Authors : Dai, Yongguo¹ (AUTHOR); Peng, Yu¹ (AUTHOR); Lu, Zhengjie^1,2 (AUTHOR)

Subjects: *Liver regeneration; *Prenatal exposure; *Somatomedin C

Source: Toxicological Sciences. May2024, Vol. 199 Issue 1, p63-80. 18p.

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Academic Journal

Organophosphate ester flame retardants and plasticizers affect the phenotype and function of HepG2 liver cells.

Authors : Yu, Dongwei¹ (AUTHOR); Hales, Barbara F¹ (AUTHOR); Robaire, Bernard^1,2 (AUTHOR)

Subjects: *Fireproofing agents; *Liver cells; *Cell survival

Source: Toxicological Sciences. Jun2024, Vol. 199 Issue 2, p261-275. 15p.

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Academic Journal

Parenteral nutrition-associated liver injury: clinical relevance and mechanistic insights.

Authors : Mihajlovic, Milos¹ (AUTHOR); Rosseel, Zenzi^2,3 (AUTHOR); Waele, Elisabeth De^3,4,5 (AUTHOR)

Subjects: *Farnesoid X receptor; *Phytosterols; *Liver injuries

Source: Toxicological Sciences. May2024, Vol. 199 Issue 1, p1-11. 11p.

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Academic Journal

Hepatocyte miR-21-5p-deficiency alleviates APAP-induced liver injury by inducing PPARγ and autophagy.

Authors : Xu, Chao^1,2 (AUTHOR) ; Yan, Fang³ (AUTHOR); Zhao, Yulan⁴ (AUTHOR)

Subjects: *Liver injuries; *Autophagy; *Liver cells

Source: Toxicological Sciences. Mar2024, Vol. 198 Issue 1, p50-60. 11p.

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Academic Journal

Extracellular vesicles altered by a per- and polyfluoroalkyl substance mixture: in vitro dose-dependent release, chemical content, and microRNA signatures involved in liver health.

Authors : Carberry, Celeste K^1,2 (AUTHOR); Bangma, Jacqueline³ (AUTHOR); Koval, Lauren^1,2 (AUTHOR)

Subjects: *Fluoroalkyl compounds; *Extracellular vesicles; *Perfluorooctanoic acidNorth Carolina

Source: Toxicological Sciences. Feb2024, Vol. 197 Issue 2, p155-169. 15p.

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Academic Journal

Mechanistic investigation of liver injury induced by BMS-932481, an experimental ɣ-secretase modulator.

Authors : Zhuo, Xiaoliang¹ (AUTHOR) ; Howell, Brett A² (AUTHOR); Shen, Hong³ (AUTHOR)

Subjects: *Liver injuries; *Bile salts; *Bile acids

Source: Toxicological Sciences. Aug2023, Vol. 194 Issue 2, p235-245. 11p.

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Academic Journal

Obesogenic polystyrene microplastic exposures disrupt the gut-liver-adipose axis.

Authors : Zhao, Jingjing^1,2 (AUTHOR); Adiele, Ngozi³ (AUTHOR); Gomes, Daniel^1,3 (AUTHOR)

Subjects: *Pollutants; *Obesogenic environment; *Farnesoid X receptor

Source: Toxicological Sciences. Apr2024, Vol. 198 Issue 2, p210-220. 11p.

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Academic Journal

A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury.

Authors : Wijaya, Lukas S¹ (AUTHOR); Gabor, Attila^2,3 (AUTHOR); Pot, Iris E¹ (AUTHOR)

Subjects: *Small interfering RNA; *RNA interference; *Liver injuries

Source: Toxicological Sciences. Mar2024, Vol. 198 Issue 1, p14-30. 17p.

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Academic Journal

Per- and polyfluoroalkyl substances (PFAS) in mixtures show additive effects on transcriptomic points of departure in human liver spheroids.

Authors : Addicks, Gregory C¹ (AUTHOR); Rowan-Carroll, Andrea¹ (AUTHOR); Reardon, Anthony J F¹ (AUTHOR)

Subjects: *Fluoroalkyl compounds; *Transcriptomes; *Liver cells

Source: Toxicological Sciences. Jul2023, Vol. 194 Issue 1, p38-52. 15p.

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Development of a human liver microphysiological coculture system for higher throughput chemical safety assessment.

Prenatal prednisone exposure impacts liver development and function in fetal mice and its characteristics.

Organophosphate ester flame retardants and plasticizers affect the phenotype and function of HepG2 liver cells.

Parenteral nutrition-associated liver injury: clinical relevance and mechanistic insights.

Hepatocyte miR-21-5p-deficiency alleviates APAP-induced liver injury by inducing PPARγ and autophagy.

Extracellular vesicles altered by a per- and polyfluoroalkyl substance mixture: in vitro dose-dependent release, chemical content, and microRNA signatures involved in liver health.

Mechanistic investigation of liver injury induced by BMS-932481, an experimental ɣ-secretase modulator.

Obesogenic polystyrene microplastic exposures disrupt the gut-liver-adipose axis.

A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury.

Per- and polyfluoroalkyl substances (PFAS) in mixtures show additive effects on transcriptomic points of departure in human liver spheroids.

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