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Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity.

• Authors : Kornberg MD; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Bhargava P

Subjects: Autoimmunity/Autoimmunity/Autoimmunity/*drug effects ; Dimethyl Fumarate/Dimethyl Fumarate/Dimethyl Fumarate/*pharmacology ; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)/Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)/Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)/*metabolism

• Source: Science (New York, N.Y.) [Science] 2018 Apr 27; Vol. 360 (6387), pp. 449-453. Date of Electronic Publication: 2018 Mar 29.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Relief and worry for immune-suppressed people.

• Authors : Couzin-Frankel J

Subjects: Immune Tolerance* ; Immunocompromised Host* ; Immunogenicity, Vaccine*

• Source: Science (New York, N.Y.) [Science] 2021 Apr 30; Vol. 372 (6541), pp. 443-444.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Developing pig-to-human organ transplants.

• Authors : Sykes, Megan¹

• Source: Science. 10/14/2022, Vol. 378 Issue 6616, p135-136. 2p. 1 Chart.

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Infectious disease. Immune suppressant unexpectedly boosts flu vaccine.

• Authors : Cohen J

Subjects: Antibodies, Viral/Antibodies, Viral/Antibodies, Viral/*immunology ; Hemagglutinin Glycoproteins, Influenza Virus/Hemagglutinin Glycoproteins, Influenza Virus/Hemagglutinin Glycoproteins, Influenza Virus/*immunology ; Immunosuppressive Agents/Immunosuppressive Agents/Immunosuppressive Agents/*administration & dosage

• Source: Science (New York, N.Y.) [Science] 2013 Oct 25; Vol. 342 (6157), pp. 413.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor.

• Authors : Changelian PS; Immunology Group, Department of Antibacterials and Immunology, Pfizer Global Researchand Development, Groton, CT 06340, USA. ; Flanagan ME

Subjects: Heart Transplantation* ; Kidney Transplantation*; Graft Rejection/Graft Rejection/Graft Rejection/*prevention & control

• Source: Science (New York, N.Y.) [Science] 2003 Oct 31; Vol. 302 (5646), pp. 875-8.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule.

• Authors : Gadek TR; Department of Bioorganic Chemistry, Genentech, One DNA Way, South San Francisco, CA 94080, USA. ; Burdick DJ

Subjects: Immunosuppressive Agents/Immunosuppressive Agents/Immunosuppressive Agents/*pharmacology ; Intercellular Adhesion Molecule-1/Intercellular Adhesion Molecule-1/Intercellular Adhesion Molecule-1/*immunology ; Intercellular Adhesion Molecule-1/Intercellular Adhesion Molecule-1/Intercellular Adhesion Molecule-1/*metabolism

• Source: Science (New York, N.Y.) [Science] 2002 Feb 08; Vol. 295 (5557), pp. 1086-9.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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On the way to a better immunosuppressant?

• Authors : Hagmann M

Subjects: Calcineurin Inhibitors* ; Nuclear Proteins*; DNA-Binding Proteins/DNA-Binding Proteins/DNA-Binding Proteins/*antagonists & inhibitors

• Source: Science (New York, N.Y.) [Science] 1999 Sep 24; Vol. 285 (5436), pp. 2042.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.

• Authors : Aramburu J; Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.; Yaffe MB

Subjects: Nuclear Proteins*; Calcineurin/Calcineurin/Calcineurin/*metabolism ; DNA-Binding Proteins/DNA-Binding Proteins/DNA-Binding Proteins/*antagonists & inhibitors

• Source: Science (New York, N.Y.) [Science] 1999 Sep 24; Vol. 285 (5436), pp. 2129-33.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Tolerating differences.

• Authors : Sikorski R; Peters R

Subjects: Immune Tolerance* ; Immunoconjugates*; Antigens, Differentiation/Antigens, Differentiation/Antigens, Differentiation/*pharmacology

• Source: Science (New York, N.Y.) [Science] 1999 Jul 16; Vol. 285 (5426), pp. 357-8.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense.

• Authors : Huang Y; Laboratory of Immunology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.; Mao K

Subjects: Immunity, Innate*; Chemotaxis/Chemotaxis/Chemotaxis/*immunology ; Interleukin-17/Interleukin-17/Interleukin-17/*immunology

• Source: Science (New York, N.Y.) [Science] 2018 Jan 05; Vol. 359 (6371), pp. 114-119.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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