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A Small Step, a Giant Leap: Somatic Hypermutation of a Single Amino Acid Leads to Anti-La Autoreactivity

Authors : Tabea Bartsch; Claudia Arndt; Liliana R. Loureiro

Subjects: QH301-705.5; autoimmunity; primary Sjögren’s syndrome

Source: International Journal of Molecular SciencesInternational Journal of Molecular Sciences 22(2021)21, 12046Volume 22Issue 21International Journal of Molecular Sciences, Vol 22,

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T Cell Mediated Conversion of a Non-Anti-La Reactive B Cell to an Autoreactive Anti-La B Cell by Somatic Hypermutation.

Authors : Bachmann MP; Department of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), 03128 Dresden, Germany.; University Cancer Center (UCC), Tumor Immunology, University Hospital Carl Gustav Carus Dresden, Technical University Dresden, 01307 Dresden, Germany.

Subjects: Somatic Hypermutation, Immunoglobulin*; Autoantigens/Autoantigens/Autoantigens/*immunology ; Autoimmunity/Autoimmunity/Autoimmunity/*genetics

Source: International journal of molecular sciences [Int J Mol Sci] 2021 Jan 26; Vol. 22 (3). Date of Electronic Publication: 2021 Jan 26.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium:

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