Search Results

Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance.

• Authors : Luth MR; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.; Godinez-Macias KP

Subjects: Antimalarials*/Antimalarials*/Antimalarials*/pharmacology ; Antimalarials*/Antimalarials*/Antimalarials*/therapeutic use ; Drug Resistance*/Drug Resistance*/Drug Resistance*/genetics

• Source: Science (New York, N.Y.) [Science] 2024 Nov 29; Vol. 386 (6725), pp. eadk9893. Date of Electronic Publication: 2024 Nov 29.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

Record details

The essential genome of Plasmodium knowlesi reveals determinants of antimalarial susceptibility.

• Authors : Elsworth B; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Laboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.

Subjects: Plasmodium knowlesi*/Plasmodium knowlesi*/Plasmodium knowlesi*/genetics ; Plasmodium knowlesi*/Plasmodium knowlesi*/Plasmodium knowlesi*/drug effects ; Antimalarials*/Antimalarials*/Antimalarials*/pharmacology

• Source: Science (New York, N.Y.) [Science] 2025 Feb 07; Vol. 387 (6734), pp. eadq6241. Date of Electronic Publication: 2025 Feb 07.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

Record details

Two codependent routes lead to high-level MRSA.

• Authors : Adedeji-Olulana, Abimbola Feyisara¹; Wacnik, Katarzyna^2,3; Lafage, Lucia^2,3

• Source: Science. 11/1/2024, Vol. 386 Issue 6721, p573-580. 8p. 4 Diagrams.

Record details

War-torn Ukraine is breeding drug-resistant bacterial strains.

• Authors : Stone R

Subjects: Bacteria*/Bacteria*/Bacteria*/classification ; Bacteria*/Bacteria*/Bacteria*/genetics ; Bacteria*/Bacteria*/Bacteria*/isolation & purification

• Source: Science (New York, N.Y.) [Science] 2024 Dec 06; Vol. 386 (6726), pp. 1085-1086. Date of Electronic Publication: 2024 Dec 05.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

Record details

Artemisinin-resistant malaria in Africa demands urgent action.

• Authors : Dhorda M; Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Subjects: Antimalarials*/Antimalarials*/Antimalarials*/therapeutic use ; Artemisinins*/Artemisinins*/Artemisinins*/therapeutic use ; Artemisinins*/Artemisinins*/Artemisinins*/pharmacology

• Source: Science (New York, N.Y.) [Science] 2024 Jul 19; Vol. 385 (6706), pp. 252-254. Date of Electronic Publication: 2024 Jul 18.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

Record details

An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance.

• Authors : Wu, Kelvin J. Y.¹; Tresco, Ben I. C.¹; Ramkissoon, Antonio¹

• Source: Science. 2/16/2024, Vol. 383 Issue 6684, p721-726. 6p. 5 Diagrams.

Record details

Degradation trumps mutations in cancer.

• Authors : Davis RE; Department of Lymphoma and Myeloma, MD Anderson Cancer Center, Houston, TX, USA.; Westin JR

Subjects: Drug Resistance, Neoplasm*/Drug Resistance, Neoplasm*/Drug Resistance, Neoplasm*/drug effects ; Drug Resistance, Neoplasm*/Drug Resistance, Neoplasm*/Drug Resistance, Neoplasm*/genetics ; Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/pharmacology

• Source: Science (New York, N.Y.) [Science] 2024 Feb 02; Vol. 383 (6682), pp. 480-481. Date of Electronic Publication: 2024 Feb 01.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

Record details

China's plan to combat antimicrobial resistance.

• Authors : Li X; Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province, Hangzhou, China.; Wu Y

Subjects: Anti-Bacterial Agents*/Anti-Bacterial Agents*/Anti-Bacterial Agents*/adverse effects ; Drug Resistance, Multiple, Bacterial* ; Antimicrobial Stewardship*/Antimicrobial Stewardship*/Antimicrobial Stewardship*/methods

• Source: Science (New York, N.Y.) [Science] 2024 Mar 29; Vol. 383 (6690), pp. 1424-1425. Date of Electronic Publication: 2024 Mar 28.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

Record details

Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127.

• Authors : Montoya S; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.; Bourcier J

Subjects: Agammaglobulinaemia Tyrosine Kinase*/Agammaglobulinaemia Tyrosine Kinase*/Agammaglobulinaemia Tyrosine Kinase*/genetics ; Agammaglobulinaemia Tyrosine Kinase*/Agammaglobulinaemia Tyrosine Kinase*/Agammaglobulinaemia Tyrosine Kinase*/metabolism ; Ikaros Transcription Factor*/Ikaros Transcription Factor*/Ikaros Transcription Factor*/metabolism

• Source: Science (New York, N.Y.) [Science] 2024 Feb 02; Vol. 383 (6682), pp. eadi5798. Date of Electronic Publication: 2024 Feb 02.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

Record details

Catalysis and Sulfa Drug Resistance in Dihydropteroate Synthase.

• Authors : Mi-Kyung Yun¹; Yinan Wu^1,2; Zhenmei Li¹

• Source: Science. 3/2/2012, Vol. 335 Issue 6072, p1110-1114. 5p.

Record details