Search Results

Canine genome-wide association study identifies DENND1B as an obesity gene in dogs and humans.

• Authors : Wallis NJ; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.; McClellan A

Subjects: Dogs*/Dogs*/Dogs*/genetics ; Dog Diseases*/Dog Diseases*/Dog Diseases*/genetics ; Obesity*/Obesity*/Obesity*/genetics

• Source: Science (New York, N.Y.) [Science] 2025 Mar 28; Vol. 387 (6741), pp. eads2145. Date of Electronic Publication: 2025 Mar 28.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation.

• Authors : Yanchus, Connor^1,2,3; Drucker, Kristen L.⁴; Kollmeyer, Thomas M.⁴

• Source: Science. 10/7/2022, Vol. 378 Issue 6615, p68-78. 11p. 5 Color Photographs.

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Single-molecule structural and kinetic studies across sequence space.

• Authors : Severins I; Department of BioNanoScience, Kavli Institute of Nanoscience, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, the Netherlands.; Biological and Soft Matter Physics, Huygens-Kamerlingh Onnes Laboratory, Leiden University, Niels Bohrweg 2, 2333 CA Leiden, Netherlands.

Subjects: DNA, Cruciform*/DNA, Cruciform*/DNA, Cruciform*/chemistry ; High-Throughput Nucleotide Sequencing* ; Single Molecule Imaging*/Single Molecule Imaging*/Single Molecule Imaging*/methods

• Source: Science (New York, N.Y.) [Science] 2024 Aug 23; Vol. 385 (6711), pp. 898-904. Date of Electronic Publication: 2024 Aug 22.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Structural mechanism of LINE-1 target-primed reverse transcription.

• Authors : Ghanim GE; MRC Laboratory of Molecular Biology, Cambridge, UK.; Hu H

Subjects: Long Interspersed Nucleotide Elements* ; Reverse Transcription*; Cryoelectron Microscopy

• Source: Science (New York, N.Y.) [Science] 2025 Apr 25; Vol. 388 (6745), pp. eads8412. Date of Electronic Publication: 2025 Apr 25.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos.

• Authors : Zuo, Erwei (AUTHOR); Sun, Yidi (AUTHOR); Wei, Wu (AUTHOR)

• Source: Science. 4/19/2019, Vol. 364 Issue 6437, p289-292. 4p. 3 Diagrams.

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Prefrontal synaptic regulation of homeostatic sleep pressure revealed through synaptic chemogenetics.

• Authors : Sawada T; International Research Center for Neurointelligence (WPI-IRCN), UTIAS, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.; Laboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Subjects: Guanine Nucleotide Exchange Factors*/Guanine Nucleotide Exchange Factors*/Guanine Nucleotide Exchange Factors*/metabolism ; Guanine Nucleotide Exchange Factors*/Guanine Nucleotide Exchange Factors*/Guanine Nucleotide Exchange Factors*/genetics ; Homeostasis*

• Source: Science (New York, N.Y.) [Science] 2024 Sep 27; Vol. 385 (6716), pp. 1459-1465. Date of Electronic Publication: 2024 Sep 26.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Sequence modeling and design from molecular to genome scale with Evo.

• Authors : Nguyen E; Arc Institute, Palo Alto, CA, USA.; Department of Bioengineering, Stanford University, Stanford, CA, USA.

Subjects: DNA*/DNA*/DNA*/genetics ; DNA*/DNA*/DNA*/chemistry ; Genomics*

• Source: Science (New York, N.Y.) [Science] 2024 Nov 15; Vol. 386 (6723), pp. eado9336. Date of Electronic Publication: 2024 Nov 15.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Massively parallel analysis of single-molecule dynamics on next-generation sequencing chips.

• Authors : Rivera, J. Aguirre¹; Mao, G.¹; Sabantsev, A.¹

• Source: Science. 8/23/2024, Vol. 385 Issue 6711, p892-898. 7p. 2 Diagrams, 1 Graph.

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Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors.

• Authors : Fugger, Kasper ; Bajrami, Ilirjana; Santos, Mariana Silva Dos

• Source: Science. 4/9/2021, Vol. 371 Issue 6538, p156-165. 10p. 6 Graphs.

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Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B.

• Authors : Zyryanova, Alisa F. (AUTHOR) ; Weis, Félix (AUTHOR); Faille, Alexandre (AUTHOR)

• Source: Science. 3/30/2018, Vol. 359 Issue 6383, p1533-1536. 4p. 3 Diagrams.

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