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Academic Journal

Biomarkers for Managing Neurodegenerative Diseases

Authors : Cheslow, Lara; Snook, Adam E.; Waldman, Scott A.

Subjects: humans; biomarkers; neurodegenerative diseases

Source: Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

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Academic Journal

Intestinal Neuropod Cell GUCY2C Regulates Visceral Pain

Authors : Barton, Joshua R.; Londregran, Annie K.; Alexander, Tyler D.

Subjects: humans; mice; animals

Source: Department of Pharmacology and Experimental Therapeutics Faculty Papers

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Academic Journal

Functional Assessment of Missense Variants in the ABCC6 Gene Implicated in Pseudoxanthoma Elasticum, a Heritable Ectopic Mineralization Disorder.

Authors : Kowal, Luke; Huang, Jianhe; Luo, Hongbin

Subjects: Adenoviridae; Animals; Calcinosis

Source: Department of Pharmacology and Experimental Therapeutics Faculty Papers

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Academic Journal

Targeting SOX10-deficient cells to reduce the dormant-invasive phenotype state in melanoma

Authors : Capparelli, Claudia; Purwin, Timothy J.; Glasheen, McKenna

Subjects: Dabrafenib; Proto Oncogene Protein; GDC-0973

Source: Department of Cancer Biology Faculty Papers

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Academic Journal

T-Cell Responses to Immunodominant Listeria Epitopes Limit Vaccine-Directed Responses to the Colorectal Cancer Antigen, Guanylyl Cyclase C

Authors : Flickinger, John C.; Singh, Jagmohan; Yarman, Yanki

Subjects: Cancer Vaccines; Colorectal Neoplasms; Epitopes

Source: Department of Pharmacology and Experimental Therapeutics Faculty Papers

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Academic Journal

Targeting gastrointestinal cancers with chimeric antigen receptor (CAR)-T cell therapy

Authors : Staudt, Ross E; Carlson, Robert D; Snook, Adam E

Subjects: CAR-T cell therapy; Immunotherapy; chimeric antigen receptor (CAR)

Source: Department of Pharmacology and Experimental Therapeutics Faculty Papers

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Academic Journal

Chimeric Ad5.F35 vector evades anti-adenovirus serotype 5 neutralization opposing GUCY2C-targeted antitumor immunity

Authors : Flickinger, John C.; Singh, Jagmohan; Carlson, Robert D

Subjects: active; gastrointestinal neoplasms; immunization

Source: Department of Pharmacology and Experimental Therapeutics Faculty Papers

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Academic Journal

Mobilizing Toxins for Cancer Treatment: Historical Perspectives and Current Strategies.

Authors : Kopenhaver, Jessica; Carlson, Robert D; Snook, Adam E

Subjects: Department of Pharmacology and Experimental Therapeutics; Thomas Jefferson University; Toxins

Source: Department of Pharmacology and Experimental Therapeutics Faculty Papers

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Academic Journal

Silencing the GUCA2A-GUCY2C tumor suppressor axis in CIN, serrated, and MSI colorectal neoplasia.

Authors : Bashir, Babar; Merlino, Dante J.; Rappaport, Jeff A.

Subjects: CDX2; Colorectal cancer; Guanylate cyclase C

Source: Department of Pharmacology and Experimental Therapeutics Faculty Papers

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Academic Journal

Split tolerance permits safe Ad5-GUCY2C-PADRE vaccine-induced T-cell responses in colon cancer patients.

Authors : Snook, Adam E.; Baybutt, Trevor R.; Xiang, Bo

Subjects: Colorectal cancer; GUCY2C; Guanylyl cyclase C

Source: Department of Pharmacology and Experimental Therapeutics Faculty Papers

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