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Academic Journal

Heat-hypersensitive mutants of ryanodine receptor type 1 revealed by microscopic heating.

Authors : Kotaro Oyama^1,2,3,4; Zeeb, Vadim⁵; Toshiko Yamazawa^6,7,8

Subjects: *RYANODINE receptors; *MALIGNANT hyperthermia; *HEAT pulses

Source: Proceedings of the National Academy of Sciences of the United States of America. 8/9/2022, Vol. 119 Issue 32, p1-31. 42p.

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Academic Journal

Molecular mechanism of the severe MH/CCD mutation Y522S in skeletal ryanodine receptor (RyR1) by cryo-EM.

Authors : Iyer, Kavita A.; Yifan Hu; Klose, Thomas

Subjects: RYANODINE receptors; ION channels; MALIGNANT hyperthermia

Source: Proceedings of the National Academy of Sciences of the United States of America; 7/26/2022, Vol. 119 Issue 30, p1-11, 11p

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Academic Journal

Dantrolene requires Mg2+ to arrest malignant hyperthermia.

Authors : Choi, Rocky H.¹; Koenig, Xaver¹; Launikonis, Bradley S.¹

Subjects: *DANTROLENE; *MALIGNANT hyperthermia; *RYANODINE receptors

Source: Proceedings of the National Academy of Sciences of the United States of America. 5/2/2017, Vol. 114 Issue 18, p4811-4815. 5p.

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Academic Journal

Malignant hyperthermia susceptibility arising from altered resting coupling between the skeletal muscle L-type Ca2+ channel and the type 1 ryanodine receptor.

Authors : Eltit, Jose Miguel^1,2; Bannister, Roger A.³; Moua, Ong⁴

Subjects: *MALIGNANT hyperthermia; *SKELETAL muscle; *EFFECT of drugs on calcium channels

Source: Proceedings of the National Academy of Sciences of the United States of America. 5/15/2012, Vol. 109 Issue 20, p7923-7928. 6p.

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Academic Journal

Characterization and temporal development of cores in a mouse model of malignant hyperthermia.

Authors : Boncompagni, Simona^1,2; Rossi, Ann E.³; Micaroni, Massimo^4,5

Subjects: *MALIGNANT hyperthermia; *MUSCLE diseases; *RYANODINE receptors

Source: Proceedings of the National Academy of Sciences of the United States of America. 12/22/2009, Vol. 106 Issue 51, p21996-22001. 6p.

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Academic Journal

A retrograde signal from RyR1 alters DHP receptor inactivation and limits window Ca[sup2+] release in muscle fibers of Y522S RyR1 knock-in mice.

Authors : Andronache51, Zoita; Hamilton, Susan L.¹; Dirksen, Robert T.²

Subjects: *MALIGNANT hyperthermia; *RYANODINE receptors; *DIHYDROPYRIDINE

Source: Proceedings of the National Academy of Sciences of the United States of America. 3/17/2009, Vol. 106 Issue 11, p4531-4536. 6p. 4 Graphs.

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Academic Journal

Thermal combination therapies for local drug delivery by magnetic resonance-guided high-intensity focused ultrasound.

Authors : Hijnen, Nicole; Kneepkens, Esther; De Smet, Mariska

Subjects: LIPOSOMES; MAGNETIC resonance; DRUG delivery systems

Source: Proceedings of the National Academy of Sciences of the United States of America; 6/13/2017, Vol. 114 Issue 24, pE4802-E4811, 10p

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Academic Journal

Mind the magnesium, in dantrolene suppression of malignant hyperthermia.

Authors : Cannon, Stephen C.

Subjects: SIDE effects of anesthetics; MUSCLE relaxants; MALIGNANT hyperthermia

Source: Proceedings of the National Academy of Sciences of the United States of America; 5/2/2017, Vol. 114 Issue 18, p4576-4578, 3p

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Academic Journal

Multiple actions of φ-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins.

Authors : Smith, Jennifer J.; Vetter, Irina; Lewis, Richard J.

Subjects: RYANODINE receptors; INTRACELLULAR calcium; DISULFIDES

Source: Proceedings of the National Academy of Sciences of the United States of America; 5/28/2013, Vol. 110 Issue 22, p8906-8911, 6p

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Academic Journal

Massive alterations of sarcoplasmic reticulum free calcium in skeletal muscle fibers lacking calsequestrin revealed by a genetically encoded probe.

Authors : Canato, M.; Scorzeto, M.; Giacomello, M.

Subjects: SARCOPLASMIC reticulum; ORGANELLES; CALCIUM

Source: Proceedings of the National Academy of Sciences of the United States of America; 12/21/2010, Vol. 107 Issue 51, p22326-22331, 6p, 1 Color Photograph, 1 Chart, 4 Graphs

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