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Robust folding of a de novo designed ideal protein even with most of the core mutated to valine

• Authors : Nobuyasu Koga; Naohiro Kobayashi; Toshihiko Sugiki

Subjects: Protein Folding; Protein Conformation; Mutant

• Source: Proceedings of the National Academy of Sciences of the United States of America

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A conserved folding nucleus sculpts the free energy landscape of bacterial and archaeal orthologs from a divergent TIM barrel family

• Authors : Michael J. Harms; C. Robert Matthews; Khaja Muneeruddin

Subjects: Models, Molecular; Protein Folding; Protein Conformation

• Source: Proceedings of the National Academy of Sciences of the United States of America

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Structural elucidation of the cis-prenyltransferase NgBR/DHDDS complex reveals insights in regulation of protein glycosylation

• Authors : Benjamin Siciliano; Eon Joo Park; William C. Sessa

Subjects: Glycosylation; Stereochemistry; Receptors, Cell Surface

• Source: Proc Natl Acad Sci U S A

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The structure of protein dynamic space

• Authors : Harold A. Scheraga; S. Rackovsky

Subjects: Physics; Sequence; Quantitative Biology::Biomolecules

• Source: Proc Natl Acad Sci U S A

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Coupled molecular dynamics mediate long- and short-range epistasis between mutations that affect stability and aggregation kinetics

• Authors : Yu, Haoran; Dalby, Paul A.

Subjects: epistasis; protein engineering; Epistasis, Genetic

• Source: Proceedings of the National Academy of Sciences of the United States of America

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Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators

• Authors : Matthew J. Henley; James A. Wells; Tomasz Cierpicki

Subjects: 0301 basic medicine; Allosteric modulator; Allosteric regulation

• Source: Proceedings of the National Academy of Sciences of the United States of America

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Spider toxin inhibits gating pore currents underlying periodic paralysis

• Authors : Michael G. Hanna; Antonina A. Berkut; Stephanie Schorge

Subjects: 0301 basic medicine; hypokalemic periodic paralysis; Neurotoxins

• Source: Proceedings of the National Academy of Sciences of the United States of America

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CTIP2 is a negative regulator of P-TEFb.

• Authors : Cherrier, Thomas; Le Douce, Valentin; Eilebrecht, Sebastian

Subjects: Animals; Cardiac Myosins/genetics/metabolism; Cardiomegaly/genetics/metabolism/pathology

• Source: Proceedings of the National Academy of Sciences of the United States of America, 110 (31), 12655-60 (2013)

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Frustration and folding of a TIM barrel protein

• Authors : Yanming Wang; Srinivas Chakravarthy; Kevin T. Halloran

Subjects: Models, Molecular; Protein Folding; Multidisciplinary

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α-Sheet secondary structure in amyloid β-peptide drives aggregation and toxicity in Alzheimer’s disease

• Authors : Matthew C. Childers; Valerie Daggett; Dylan Shea

Subjects: Amyloid; Amyloid beta; Immunoblotting

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