Search Results

Integrating multiscale mathematical modeling and multidimensional data reveals the effects of epigenetic instability on acquired drug resistance in cancer.

• Authors : Wang, Shun¹ (AUTHOR); Lei, Jinzhi² (AUTHOR); Zou, Xiufen¹ (AUTHOR)

• Source: PLoS Computational Biology. 2/14/2025, Vol. 21 Issue 2, p1-24. 24p.

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St-N, a novel alkaline derivative of stevioside, reverses docetaxel resistance by targeting lysosomes in vitro and in vivo.

• Authors : Guo, Yanxia^1,2 (AUTHOR); Wang, Shikang³ (AUTHOR); Liu, Qun⁴ (AUTHOR)

Subjects: *DRUG resistance in cancer cells; *TRANSMISSION electron microscopy; *MEMBRANE proteins

• Source: PLoS ONE. 12/27/2024, Vol. 19 Issue 12, p1-17. 17p.

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miR-1247-3p regulation of CCND1 affects chemoresistance in colorectal cancer.

• Authors : Wang, Dequan¹ (AUTHOR); Wang, Jielian² (AUTHOR); Yao, Fei³ (AUTHOR)

Subjects: *GENE expression; *NON-coding RNA; *DRUG resistance

• Source: PLoS ONE. 12/31/2024, Vol. 19 Issue 12, p1-15. 15p.

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Sparse spectral graph analysis and its application to gastric cancer drug resistance-specific molecular interplays identification.

• Authors : Park, Heewon¹ (AUTHOR) ; Miyano, Satoru^2,3 (AUTHOR)

Subjects: *STOMACH cancer; *SPARSE graphs; *DRUG resistance in cancer cells

• Source: PLoS ONE. 7/5/2024, Vol. 19 Issue 7, p1-22. 22p.

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A novel TOX3-WDR5-ABCG2 signaling axis regulates the progression of colorectal cancer by accelerating stem-like traits and chemoresistance.

• Authors : Hao, Jiaojiao¹ (AUTHOR); Huang, Jinsheng² (AUTHOR); Hua, Chunyu¹ (AUTHOR)

• Source: PLoS Biology. 9/14/2023, Vol. 21 Issue 9, p1-29. 29p. 5 Diagrams, 2 Graphs.

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MicroRNA-21 induces cisplatin resistance in head and neck squamous cell carcinoma.

• Authors : Sheng, Shuyan¹ (AUTHOR); Su, Wenzhuo² (AUTHOR); Mao, Deshen¹ (AUTHOR)

Subjects: *DRUG resistance in cancer cells; *SQUAMOUS cell carcinoma; *CELL death

• Source: PLoS ONE. 4/14/2022, Vol. 17 Issue 4, p1-15. 15p.

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Copper binding leads to increased dynamics in the regulatory N-terminal domain of full-length human copper transporter ATP7B.

• Authors : Orädd, Fredrik¹ (AUTHOR); Steffen, Jonas Hyld² (AUTHOR); Gourdon, Pontus^2,3 (AUTHOR)

• Source: PLoS Computational Biology. 9/7/2022, Vol. 18 Issue 9, p1-21. 21p. 2 Diagrams, 4 Graphs.

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Calotropis gigantea stem bark extract induced apoptosis related to ROS and ATP production in colon cancer cells.

• Authors : Winitchaikul, Thanwarat¹ (AUTHOR); Sawong, Suphunwadee¹ (AUTHOR); Surangkul, Damratsamon² (AUTHOR)

Subjects: *CANCER cells; *DRUG resistance in cancer cells; *BARK

• Source: PLoS ONE. 8/3/2021, Vol. 16 Issue 8, p1-24. 24p.

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Acquired chemoresistance drives spatial heterogeneity, chemoprotection and collective migration in pancreatic tumor spheroids.

• Authors : Thege, Fredrik I.¹ (AUTHOR); Cardle, Ian I.¹ (AUTHOR); Gruber, Conor N.¹ (AUTHOR)

Subjects: *PANCREATIC tumors; *DRUG resistance in cancer cells; *CELL populations

• Source: PLoS ONE. 5/26/2022, Vol. 17 Issue 5, p1-26. 26p.

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Use of CRISPR/Cas9 with homology-directed repair to silence the human topoisomerase IIα intron-19 5' splice site: Generation of etoposide resistance in human leukemia K562 cells.

• Authors : Hernandez, Victor A.¹ (AUTHOR); Carvajal-Moreno, Jessika¹ (AUTHOR); Wang, Xinyi¹ (AUTHOR)

Subjects: *DNA topoisomerase I; *DRUG resistance in cancer cells; *RNA splicing

• Source: PLoS ONE. 5/26/2022, Vol. 17 Issue 5, p1-26. 26p.

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