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Academic Journal

Neutralizing IFN-γ autoantibodies are rare and pathogenic in HLA-DRB1*15:02 or 16:02 individuals.

Authors : Peel, Jessica; Yang, Rui; Le Voyer, Tom

Subjects: Autoimmune diseases; Cytokines; Genetics

Source: The Journal of Clinical Investigation. 134(8)

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Academic Journal

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Authors : Matuozzo, Daniela; Talouarn, Estelle; Marchal, Astrid

Subjects: Clinical Research; Infectious Diseases; Pneumonia & Influenza

Source: Genome Medicine. 15(1)

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Academic Journal

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Authors : Bastard, Paul; Gervais, Adrian; Le Voyer, Tom

Subjects: Pneumonia; Lung; Infectious Diseases

Source: Science Immunology. 6(62)

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Academic Journal

Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1

Authors : Bastard, Paul; Orlova, Elizaveta; Sozaeva, Leila

Subjects: Biomedical and Clinical Sciences; Clinical Sciences; Prevention

Source: Journal of Experimental Medicine. 218(7)

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Academic Journal

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

Authors : Manry, Jérémy; Bastard, Paul; Gervais, Adrian

Subjects: autoantibodies; COVID-19; infection fatality rate

Source: Manry , J , Bastard , P , Gervais , A , Le Voyer , T , Rosain , J , Philippot , Q , Michailidis , E , Hoffmann , H H , Eto , S , Garcia-Prat , M , Bizien , L ,

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Academic Journal

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19.

Authors : Asano, Takaki; Boisson, Bertrand; Onodi, Fanny ...

Subjects: Adolescent; Adult; Aged

Source: Science immunology, Vol. 6, no.62, p. e (2021)

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Academic Journal

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19.

Authors : Casanova, Jean-Laurent; Puel, Anne; Zhang, Qian ...

Subjects: Adolescent; Adult; Aged

Source: Science immunology, Vol. 6, no. 62 (2021) (2021)

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