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Academic Journal

Calories from carbohydrates: energetic contribution of the carbohydrate moiety of rebeccamycin to DNA binding and the effect of its orientation on topoisomerase I inhibition

Subjects: Models, Molecular; 0301 basic medicine; Indoles

  • Source: Chemistry & Biology. 6:277-286

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Academic Journal

Rebeccamycin Derivatives as Dual DNA-Damaging Agents and Potent Checkpoint Kinase 1 Inhibitors

Subjects: 0301 basic medicine; [SDV.BBM]Life Sciences [q-bio]/Biochemistry; Carbazoles

  • Source: Molecular PharmacologyMolecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2008, 74 (6), pp.1620-1629. ⟨10.1124/mol.108.049346⟩Molecular

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Academic Journal

Crystallographic trapping in the rebeccamycin biosynthetic enzyme RebC

Subjects: 0301 basic medicine; Indoles; Protein Conformation

  • Source: Proceedings of the National Academy of Sciences. 104:15311-15316

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Academic Journal

A phase I study of rebeccamycin analog in combination with oxaliplatin in patients with refractory solid tumors

Subjects: Adult; Aged, 80 and over; Male

  • Source: Investigational New Drugs. 29:126-130

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Academic Journal

Phase II and pharmacokinetic trial of rebeccamycin analog in advanced biliary cancers

Subjects: Male; 0301 basic medicine; Neutropenia

  • Source: Cancer Chemotherapy and Pharmacology. 65:73-78

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Academic Journal

The Biosynthetic Gene Cluster for the Antitumor Rebeccamycin

Subjects: Pharmacology; 0301 basic medicine; Indoles

  • Source: Chemistry & Biology. 9:519-531

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Academic Journal

Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells

Subjects: Adenosine Triphosphatases; Azides; Lung Neoplasms

  • Source: Cancer Chemotherapy and Pharmacology. 64:575-583

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Academic Journal

N-Glycoside of Indolo[2,3- a ]pyrrolo[3,4- c ]carbazole LCS1269 Exerts Anti-Glioblastoma Effects by G2 Cell Cycle Arrest and CDK1 Activity Modulation: Molecular Docking Studies, Biological Investigations, and ADMET Prediction.

Subjects: BINDING sites; MOLECULAR docking; CELL cycle

  • Source: Pharmaceuticals (14248247); Dec2024, Vol. 17 Issue 12, p1642, 20p

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Academic Journal

Molecular Mechanisms of Anticancer Activity of N-Glycosides of Indolocarbazoles LCS-1208 and LCS-1269.

  • Authors : Zenkov RG; N. N. Blokhin Russian Cancer Research Center, 24 Kashirskoe Shosse, 115478 Moscow, Russia.; Vlasova OA

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Carbazoles/Carbazoles/Carbazoles/*pharmacology ; Glycosides/Glycosides/Glycosides/*pharmacology

  • Source: Molecules (Basel, Switzerland) [Molecules] 2021 Dec 02; Vol. 26 (23). Date of Electronic Publication: 2021 Dec 02.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Combinatorial biosynthesis of antitumor indolocarbazole compounds

Subjects: 0301 basic medicine; 03 medical and health sciences; Indoles

  • Source: Proceedings of the National Academy of Sciences. 102:461-466

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  • 1-10 of  20 results for ""rebeccamycin""