Search Results

Low dose DNA methyltransferase inhibitors potentiate PARP inhibitors in homologous recombination repair deficient tumors

• Authors : Pacaud, Romain; Thomas, Scott; Chaudhuri, Sibapriya

Subjects: Biomedical and Clinical Sciences; Oncology and Carcinogenesis; Breast Cancer

• Source: Breast Cancer Research. 27(1)

Record details

Homologous Recombination Deficiency (HRD) in Cutaneous Oncology.

• Authors : Akinjiyan, Favour; Morecroft, Renee; Phillipps, Jordan

Subjects: DNA repair; PARP inhibitors; genomic scars

• Source: International Journal of Molecular Sciences. 24(13)

Record details

A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors.

• Authors : Zhou, Jia; Gelot, Camille; Pantelidou, Constantia

Subjects: Fanconi Anemia; HRD cancer; Homologous Recombination

• Source: Nature Cancer. 2(6)

Record details

Glycogen synthase kinase 3β inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer.

• Authors : Zhang, Ning; Tian, Yu-Nan; Zhou, Li-Na

Subjects: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line

• Source: Cell Death and Disease. 12(2)

Record details

Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors

• Authors : Lahiguera, Álvaro; Hyroššová, Petra; Figueras, Agnès

Subjects: Cancer; Genetics; Biotechnology

• Source: EMBO Molecular Medicine. 12(6)

Record details

TTK inhibition radiosensitizes basal-like breast cancer through impaired homologous recombination

• Authors : Chandler, Benjamin C; Moubadder, Leah; Ritter, Cassandra L

Subjects: Biological Sciences; Biomedical and Clinical Sciences; Oncology and Carcinogenesis

• Source: Journal of Clinical Investigation. 130(2)

Record details

Prevalence of Homologous Recombination Deficiency Among Patients With Germline RAD51C/D Breast or Ovarian Cancer

• Authors : Torres-Esquius, Sara; Llop-Guevara, Alba; Gutiérrez-Enríquez, Sara

Subjects: Adult; Aged; Breast Neoplasms

Record details

Combining Homologous Recombination-Deficient Testing and Functional RAD51 Analysis Enhances the Prediction of Poly(ADP-Ribose) Polymerase Inhibitor Sensitivity

• Authors : Korsholm, Lea M; Kjeldsen, Maj; Perino, Lorenzo

Subjects: Humans; Female; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology

• Source: Korsholm , L M , Kjeldsen , M , Perino , L , Mariani , L , Nyvang , G-B , Kristensen , E , Bagger , F O , Mirza , M R & Rossing , M 2024 , ' Combining Homologous

Record details

Natural product β-thujaplicin inhibits homologous recombination repair and sensitizes cancer cells to radiation therapy

• Authors : Zhang, Lihong; Peng, Yang; Uray, Ivan P

Subjects: Biochemistry and Cell Biology; Biological Sciences; Genetics

Record details

ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells

• Authors : Yazinski, Stephanie A; Comaills, Valentine; Buisson, Rémi

Subjects: Biomedical and Clinical Sciences; Oncology and Carcinogenesis; Genetics

• Source: Genes & Development. 31(3)

Record details