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Academic Journal

The MDM2 inhibitor CGM097 combined with the BET inhibitor OTX015 induces cell death and inhibits tumor growth in models of neuroblastoma.

Authors : Maser T; Pediatric Oncology Translational Research Program, Helen DeVos Children's Hospital, Grand Rapids, MI, USA.; Zagorski J

Subjects: Acetanilides/Acetanilides/Acetanilides/*pharmacology ; Heterocyclic Compounds, 3-Ring/Heterocyclic Compounds, 3-Ring/Heterocyclic Compounds, 3-Ring/*pharmacology ; Isoquinolines/Isoquinolines/Isoquinolines/*pharmacology

Source: Cancer medicine [Cancer Med] 2020 Nov; Vol. 9 (21), pp. 8144-8158. Date of Electronic Publication: 2020 Oct 09.Publisher: John Wiley & Sons Ltd Country of Publication: United States NLM ID: 101595310 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Synthesis and biological evaluation of N-arylpiperazine derivatives of 4,4-dimethylisoquinoline-1,3(2H,4H)-dione as potential antiplatelet agents.

Authors : Marcinkowska M; a Department of Medicinal Chemistry , Jagiellonian University Medical College , Kraków , Poland.; Kotańska M

Subjects: Isoquinolines/Isoquinolines/Isoquinolines/*pharmacology ; Piperazines/Piperazines/Piperazines/*pharmacology ; Platelet Aggregation Inhibitors/Platelet Aggregation Inhibitors/Platelet Aggregation Inhibitors/*pharmacology

Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2018 Dec; Vol. 33 (1), pp. 536-545.Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print Cited Medium: Internet ISSN: 1475-6374

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Academic Journal

Inhibition of Autotaxin and Lysophosphatidic Acid Receptor 5 Attenuates Neuroinflammation in LPS-Activated BV-2 Microglia and a Mouse Endotoxemia Model.

Authors : Joshi L; Division of Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, 8010 Graz, Austria.; Plastira I

Subjects: Endotoxemia*/Endotoxemia*/Endotoxemia*/chemically induced ; Endotoxemia*/Endotoxemia*/Endotoxemia*/metabolism ; Endotoxemia*/Endotoxemia*/Endotoxemia*/pathology

Source: International journal of molecular sciences [Int J Mol Sci] 2021 Aug 07; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 07.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

5-Isoquinolinesulfonamide derivatives. III. Synthesis and vasodilatory activity of 1-(5-isoquinoline-sulfonyl)piperazine derivatives.

Authors : Morikawa A; Life-science Institute, Asahi Chemical Industry Co., Ltd., Miyazaki, Japan.; Sone T

Subjects: Isoquinolines/Isoquinolines/Isoquinolines/*chemical synthesis ; Piperazines/Piperazines/Piperazines/*chemical synthesis ; Vasodilator Agents/Vasodilator Agents/Vasodilator Agents/*chemical synthesis

Source: Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 1992 Mar; Vol. 40 (3), pp. 770-3.Publisher: Pharmaceutical Society of Japan Country of Publication: Japan NLM ID: 0377775 Publication Model: Print Cited Medium: Print ISSN:

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Academic Journal

Synthesis of renieramycins: construction of the core ring system of cribrostatin 4 through modified Pictet-Spengler cyclization of 3,6-bisarylpiperazine-2,5-dione with diethoxyethyl benzoate.

Authors : Yokoya M; Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo, Japan.; Ito H

Subjects: Benzoates/Benzoates/Benzoates/*chemistry ; Isoquinolines/Isoquinolines/Isoquinolines/*chemistry ; Piperazines/Piperazines/Piperazines/*chemistry

Source: Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 2011; Vol. 59 (6), pp. 787-92.Publisher: Pharmaceutical Society of Japan Country of Publication: Japan NLM ID: 0377775 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Protein kinase inhibitor H-7 increases lipoprotein lipase activity in isolated rat fat pads.

Authors : Morita T; Department of Biochemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Japan.; Tsuruzono Y

Subjects: Protein Kinase Inhibitors*; Adipose Tissue/Adipose Tissue/Adipose Tissue/*enzymology ; Isoquinolines/Isoquinolines/Isoquinolines/*pharmacology

Source: Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 1991 Sep; Vol. 39 (9), pp. 2449-50.Publisher: Pharmaceutical Society of Japan Country of Publication: Japan NLM ID: 0377775 Publication Model: Print Cited Medium: Print ISSN:

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Academic Journal

Differential sensitivity of pancreatic beta-cells to phorbol ester TPA and C-kinase inhibitor H-7 in nonpregnant and pregnant rats.

Authors : Tanigawa K; Department of Medicine, Shimane Medical University, Japan.; Tsuchiyama S

Subjects: Insulin/Insulin/Insulin/*metabolism ; Islets of Langerhans/Islets of Langerhans/Islets of Langerhans/*drug effects ; Isoquinolines/Isoquinolines/Isoquinolines/*pharmacology

Source: Endocrinologia japonica [Endocrinol Jpn] 1990 Dec; Vol. 37 (6), pp. 883-91.Publisher: Jikei University School Of Medicine Department Of Anatomy Country of Publication: Japan NLM ID: 0376546 Publication Model: Print Cited Medium:

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Academic Journal

Dissimilar effects of the protein kinase C inhibitors, staurosporine and H-7, on cholecystokinin-induced enzyme secretion from rabbit pancreatic acini.

Authors : Ederveen AG; Department of Biochemistry, University of Nijmegen, The Netherlands.; Van Emst-De Vries SE

Subjects: Alkaloids/Alkaloids/Alkaloids/*pharmacology ; Cholecystokinin/Cholecystokinin/Cholecystokinin/*pharmacology ; Isoquinolines/Isoquinolines/Isoquinolines/*pharmacology

Source: European journal of biochemistry [Eur J Biochem] 1990 Oct 05; Vol. 193 (1), pp. 291-5.Publisher: Blackwell Science Ltd. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 0107600 Publication Model:

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Academic Journal

Pertussis toxin and H-7 distinguish mechanisms involved in eicosanoid release from lipopolysaccharide-primed macrophages. Eicosanoid release from lipopolysaccharide-primed macrophages.

Authors : Matsunaga A; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235-9038.; Miller BC

Subjects: Pertussis Toxin*; Eicosanoids/Eicosanoids/Eicosanoids/*metabolism ; Isoquinolines/Isoquinolines/Isoquinolines/*pharmacology

Source: European journal of biochemistry [Eur J Biochem] 1990 Feb 14; Vol. 187 (3), pp. 599-603.Publisher: Blackwell Science Ltd. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 0107600 Publication Model:

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Academic Journal

Effect of protein kinase C inhibitor (H-7) and calmodulin antagonist (W-7) on pertussis toxin-induced IL-1 production by human adherent monocytes. Comparison with lipopolysaccharide as a stimulator of IL-1 production.

Authors : Taniguchi H; Department of Pediatrics, Hiroshima University School of Medicine, Japan.; Sakano T

Subjects: Lipopolysaccharides* ; Pertussis Toxin* ; Virulence Factors, Bordetella*

Source: Immunology [Immunology] 1989 Jun; Vol. 67 (2), pp. 210-5.Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 0374672 Publication Model: Print Cited Medium: Print ISSN:

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The MDM2 inhibitor CGM097 combined with the BET inhibitor OTX015 induces cell death and inhibits tumor growth in models of neuroblastoma.

Synthesis and biological evaluation of N-arylpiperazine derivatives of 4,4-dimethylisoquinoline-1,3(2H,4H)-dione as potential antiplatelet agents.

Inhibition of Autotaxin and Lysophosphatidic Acid Receptor 5 Attenuates Neuroinflammation in LPS-Activated BV-2 Microglia and a Mouse Endotoxemia Model.

5-Isoquinolinesulfonamide derivatives. III. Synthesis and vasodilatory activity of 1-(5-isoquinoline-sulfonyl)piperazine derivatives.

Synthesis of renieramycins: construction of the core ring system of cribrostatin 4 through modified Pictet-Spengler cyclization of 3,6-bisarylpiperazine-2,5-dione with diethoxyethyl benzoate.

Protein kinase inhibitor H-7 increases lipoprotein lipase activity in isolated rat fat pads.

Differential sensitivity of pancreatic beta-cells to phorbol ester TPA and C-kinase inhibitor H-7 in nonpregnant and pregnant rats.

Dissimilar effects of the protein kinase C inhibitors, staurosporine and H-7, on cholecystokinin-induced enzyme secretion from rabbit pancreatic acini.

Pertussis toxin and H-7 distinguish mechanisms involved in eicosanoid release from lipopolysaccharide-primed macrophages. Eicosanoid release from lipopolysaccharide-primed macrophages.

Effect of protein kinase C inhibitor (H-7) and calmodulin antagonist (W-7) on pertussis toxin-induced IL-1 production by human adherent monocytes. Comparison with lipopolysaccharide as a stimulator of IL-1 production.

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