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Academic Journal

Optimization of Clinical Trial Design and Decision-Making for Heart Failure with Preserved Ejection Fraction (HFpEF): A Meta-Analysis Based on a Placebo Response Model.

  • Authors : Chen X; Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Yang J

Subjects: Heart Failure*/Heart Failure*/Heart Failure*/physiopathology ; Heart Failure*/Heart Failure*/Heart Failure*/mortality ; Heart Failure*/Heart Failure*/Heart Failure*/drug therapy

  • Source: Cardiovascular therapeutics [Cardiovasc Ther] 2025 Oct 06; Vol. 2025, pp. 7087720. Date of Electronic Publication: 2025 Oct 06 (Print Publication: 2025).Publisher: Hindawi Country of Publication: England NLM ID: 101319630 Publication Model: eCollection Cited Medium: Internet ISSN: 1755-5922

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Academic Journal

Type 2 diabetes, sodium-glucose cotransporter-2 inhibitors and cardiovascular outcomes: real world evidence versus a randomised clinical trial.

Subjects: Sodium-Glucose Transporter 2 Inhibitors*/Sodium-Glucose Transporter 2 Inhibitors*/Sodium-Glucose Transporter 2 Inhibitors*/therapeutic use ; Sodium-Glucose Transporter 2 Inhibitors*/Sodium-Glucose Transporter 2 Inhibitors*/Sodium-Glucose Transporter 2 Inhibitors*/adverse effects ; Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/Diabetes Mellitus, Type 2*/drug therapy

  • Source: Cardiovascular diabetology [Cardiovasc Diabetol] 2025 Sep 30; Vol. 24 (1), pp. 371. Date of Electronic Publication: 2025 Sep 30.Publisher: BioMed Central Country of Publication: England NLM ID: 101147637 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2840

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Academic Journal

Developing a surgical trial intervention protocol: using qualitative methods in the operating theatre.

  • Authors : Twiddy M; Institute of Clinical and Applied Health Research, Hull York Medical School, University of Hull, Cottingham Road, Hull, HU6 7RX, England. .; Jackson R

Subjects: Thyroidectomy*/Thyroidectomy*/Thyroidectomy*/adverse effects ; Thyroidectomy*/Thyroidectomy*/Thyroidectomy*/methods ; Operating Rooms*

  • Source: Trials [Trials] 2025 Sep 26; Vol. 26 (1), pp. 368. Date of Electronic Publication: 2025 Sep 26.Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215

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Academic Journal

Comparison of methods for identifying the optimal treatment duration in randomized trials for antibiotics.

  • Authors : Dufault SM; Division of Biostatistics, Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA. .; UCSF Center for Tuberculosis, San Francisco, CA, USA. .

Subjects: Randomized Controlled Trials as Topic*/Randomized Controlled Trials as Topic*/Randomized Controlled Trials as Topic*/methods ; Anti-Bacterial Agents*/Anti-Bacterial Agents*/Anti-Bacterial Agents*/administration & dosage ; Anti-Bacterial Agents*/Anti-Bacterial Agents*/Anti-Bacterial Agents*/adverse effects

  • Source: Trials [Trials] 2025 Sep 24; Vol. 26 (1), pp. 352. Date of Electronic Publication: 2025 Sep 24.Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215

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Academic Journal

AI-NLME: A New Artificial Intelligence-Driven Nonlinear Mixed Effect Modeling Approach for Analyzing Longitudinal Data in Randomized Placebo-Controlled Clinical Trials.

Subjects: Randomized Controlled Trials as Topic*/Randomized Controlled Trials as Topic*/Randomized Controlled Trials as Topic*/methods ; Randomized Controlled Trials as Topic*/Randomized Controlled Trials as Topic*/Randomized Controlled Trials as Topic*/statistics & numerical data ; Artificial Intelligence*

  • Source: Clinical and translational science [Clin Transl Sci] 2025 Sep; Vol. 18 (9), pp. e70345.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Efficacy of a single intra-articular injection of mesenchymal stem cells for knee osteoarthritis: a dose-focused meta-analysis of randomized controlled trials.

  • Authors : Rahmadian R; Orthopaedic and Traumatology Division, Department of Surgery, Faculty of Medicine, M. Djamil General Hospital, Universitas Andalas, Padang, Indonesia. .; Tissue Bank and Cell Department, M. Djamil General Hospital, Padang, Indonesia. .

Subjects: Osteoarthritis, Knee*/Osteoarthritis, Knee*/Osteoarthritis, Knee*/therapy ; Mesenchymal Stem Cell Transplantation*/Mesenchymal Stem Cell Transplantation*/Mesenchymal Stem Cell Transplantation*/methods ; Randomized Controlled Trials as Topic*/Randomized Controlled Trials as Topic*/Randomized Controlled Trials as Topic*/methods

  • Source: Journal of orthopaedic surgery and research [J Orthop Surg Res] 2025 Aug 30; Vol. 20 (1), pp. 812. Date of Electronic Publication: 2025 Aug 30.Publisher: BioMed Central Country of Publication: England NLM ID: 101265112 Publication Model: Electronic Cited Medium: Internet ISSN: 1749-799X

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Academic Journal

The efficacy of colchicine compared to placebo for preventing ischemic stroke among individuals with established atherosclerotic cardiovascular diseases: a systematic review and meta-analysis.

  • Authors : Zhu S; Department of Neurology, The Second Hospital of Liaocheng Affiliated to Shandong First Medical University, Linqing, China.; Pan W

Subjects: Colchicine*/Colchicine*/Colchicine*/therapeutic use ; Colchicine*/Colchicine*/Colchicine*/adverse effects ; Ischemic Stroke*/Ischemic Stroke*/Ischemic Stroke*/prevention & control

  • Source: Scandinavian cardiovascular journal : SCJ [Scand Cardiovasc J] 2025 Dec; Vol. 59 (1), pp. 2441112. Date of Electronic Publication: 2024 Dec 21.Publisher: Taylor & Francis Country of Publication: England NLM ID: 9708377 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Comparing randomized trial designs to estimate treatment effect in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias using the SARA score.

Subjects: Randomized Controlled Trials as Topic*/Randomized Controlled Trials as Topic*/Randomized Controlled Trials as Topic*/methods ; Cerebellar Ataxia*/Cerebellar Ataxia*/Cerebellar Ataxia*/therapy ; Cerebellar Ataxia*/Cerebellar Ataxia*/Cerebellar Ataxia*/genetics

  • Source: BMC medical research methodology [BMC Med Res Methodol] 2025 Jul 30; Vol. 25 (1), pp. 179. Date of Electronic Publication: 2025 Jul 30.Publisher: BioMed Central Country of Publication: England NLM ID: 100968545 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2288

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Academic Journal

Trastuzumab in early curative breast cancer: A target trial emulation benchmarked against two randomized clinical trials.

  • Authors : Voelskow V; Institute of Public Health, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Unit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Subjects: Breast Neoplasms*/Breast Neoplasms*/Breast Neoplasms*/drug therapy ; Breast Neoplasms*/Breast Neoplasms*/Breast Neoplasms*/pathology ; Breast Neoplasms*/Breast Neoplasms*/Breast Neoplasms*/mortality

  • Source: PLoS medicine [PLoS Med] 2025 Jul 21; Vol. 22 (7), pp. e1004661. Date of Electronic Publication: 2025 Jul 21 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101231360 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

The efficacy of platelet-rich plasma preparation protocols in the treatment of osteoarthritis: a network meta-analysis of randomized controlled trials.

  • Authors : Yu D; Center for Rehabilitation Medicine, Department of Orthopedics, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.; Zhao J

Subjects: Osteoarthritis, Knee*/Osteoarthritis, Knee*/Osteoarthritis, Knee*/therapy ; Platelet-Rich Plasma* ; Randomized Controlled Trials as Topic*/Randomized Controlled Trials as Topic*/Randomized Controlled Trials as Topic*/methods

  • Source: Journal of orthopaedic surgery and research [J Orthop Surg Res] 2025 Jun 24; Vol. 20 (1), pp. 614. Date of Electronic Publication: 2025 Jun 24.Publisher: BioMed Central Country of Publication: England NLM ID: 101265112 Publication Model: Electronic Cited Medium: Internet ISSN: 1749-799X

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  • 1-10 of  9,006 results for ""treatment outcome""