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Interleukin-6: Genetics, Clinical Applications and Role in Disease

• Authors : DeVito, Edward N.; D'Aquino, Jovanni

Subjects: Cytokines--Physiological effect; Interleukin-6; Inflammation--Molecular aspectsMEDICAL / Immunology

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Utility of interleukin-6 to identify serious bacterial infections in febrile infants aged ≤60 days

• Authors : Orfanos, Ioannis; Krusell, Emilie Thorén; Elfving, Kristina ...

Subjects: Medical and Health Sciences; Clinical Medicine; Pediatrics

• Source: Acta Pædiatrica. 114(1):173-179

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Bi-allelic NRXN1α deletion in microglia derived from iPSC of an autistic patient increases interleukin-6 production and impairs supporting function on neuronal networking

• Authors : Bose, Raj; Posada-Pérez, Mercedes; Karvela, Eleni ...

Subjects: Medical and Health Sciences; Basic Medicine; Neurosciences

• Source: Brain, Behavior, and Immunity. 123:28-42

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Evaluating transforming growth factor-B and interleukin-6 as a prognostic markers in pediatric critically ill septic patients.

• Authors : Eskander, Ayman Emil¹ (AUTHOR) ; Rady, Hanaa Ibrahim¹ (AUTHOR) ; Balah, Mariam Mahmoud¹ (AUTHOR)

• Source: Egyptian Pediatric Association Gazette. 7/2/2025, Vol. 73 Issue 1, p1-8. 8p.

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Differential roles of interleukin-6 and adrenomedullin in early diagnosis and mortality predictions in late-onset neonatal sepsis.

• Authors : Henrique dos Santos, Emilly^1,2; Acca Barreira, Gabriel^1,2,3; Okay Saippa, Mariana^1,4

• Source: Clinical & Experimental Pediatrics. Jun2025, Vol. 68 Issue 6, p463-471. 9p.

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Novel treatment strategy targeting interleukin-6 induced by cancer associated fibroblasts for peritoneal metastasis of gastric cancer.

• Authors : Mitsui E; Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558, Japan.; Kikuchi S

Subjects: Stomach Neoplasms*/Stomach Neoplasms*/Stomach Neoplasms*/pathology ; Stomach Neoplasms*/Stomach Neoplasms*/Stomach Neoplasms*/metabolism ; Stomach Neoplasms*/Stomach Neoplasms*/Stomach Neoplasms*/drug therapy

• Source: Scientific reports [Sci Rep] 2025 Jan 25; Vol. 15 (1), pp. 3267. Date of Electronic Publication: 2025 Jan 25.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Interleukin-6: Cardiovascular Aspects of Long-Term Cytokine Suppression in Patients with Rheumatoid Arthritis.

• Authors : Gerasimova EV; Department of Systemic Rheumatic Diseases, V.A. Nasonova Research Institute of Rheumatology, Kashirskoe Shosse, 115522 Moscow, Russia.; Popkova TV

Subjects: Arthritis, Rheumatoid*/Arthritis, Rheumatoid*/Arthritis, Rheumatoid*/drug therapy ; Arthritis, Rheumatoid*/Arthritis, Rheumatoid*/Arthritis, Rheumatoid*/metabolism ; Antibodies, Monoclonal, Humanized*/Antibodies, Monoclonal, Humanized*/Antibodies, Monoclonal, Humanized*/therapeutic use

• Source: International journal of molecular sciences [Int J Mol Sci] 2024 Nov 19; Vol. 25 (22). Date of Electronic Publication: 2024 Nov 19.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Changes in olfactory function and serum interleukin-6 levels in the acute phase of bipolar I disorder: a longitudinal study.

• Authors : Yang C; Department of Psychiatry, The Fourth People's Hospital of Shunde District (Shunde WuZhongpei Memorial Hospital), Foshan City, Guangdong, 528300, China.; Zhou Z

Subjects: Interleukin-6*/Interleukin-6*/Interleukin-6*/blood ; Bipolar Disorder*/Bipolar Disorder*/Bipolar Disorder*/blood ; Bipolar Disorder*/Bipolar Disorder*/Bipolar Disorder*/physiopathology

• Source: BMC psychiatry [BMC Psychiatry] 2025 Jul 01; Vol. 25 (1), pp. 605. Date of Electronic Publication: 2025 Jul 01.Publisher: BioMed Central Country of Publication: England NLM ID: 100968559 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-244X

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Hsa-miR-21-5p is induced by interleukin-6 and affects multiple pathogenic factors associated with fibroblast-like synoviocytes in rheumatoid arthritis.

• Authors : Araki K; Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, 734- 8551, Japan.; Mokuda S

Subjects: Arthritis, Rheumatoid*/Arthritis, Rheumatoid*/Arthritis, Rheumatoid*/pathology ; Arthritis, Rheumatoid*/Arthritis, Rheumatoid*/Arthritis, Rheumatoid*/genetics ; Arthritis, Rheumatoid*/Arthritis, Rheumatoid*/Arthritis, Rheumatoid*/metabolism

• Source: Scientific reports [Sci Rep] 2025 Jun 03; Vol. 15 (1), pp. 19416. Date of Electronic Publication: 2025 Jun 03.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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RNase 7 and Th cytokines synergistically increase the secretion of interleukin-6 from keratinocytes.

• Authors : Chopra S; Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.; Siegl J

Subjects: Keratinocytes*/Keratinocytes*/Keratinocytes*/metabolism ; Keratinocytes*/Keratinocytes*/Keratinocytes*/drug effects ; Interleukin-6*/Interleukin-6*/Interleukin-6*/metabolism

• Source: Scientific reports [Sci Rep] 2025 Jun 03; Vol. 15 (1), pp. 19396. Date of Electronic Publication: 2025 Jun 03.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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