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Endoscopic retrograde cholangiopancreatography of geriatric patients with cholangitis: A single-center experience in central Saudi Arabia Background: Endoscopic retrograde cholangiopancreatography (ERCP) is an essential tool for managing biliary diseases, particularly in geriatric patients. However, limited data exists on its safety and efficacy in geriatric population in Saudi Arabia. Methods: This prospective study evaluated ERCP outcomes in patients aged ≥70 at Prince Sultan Military Medical City, Riyadh, between November 2023 and May 2025. Patients were categorized into two groups: 70–80 years and ≥81 years. Data collected included demographics, comorbidities, Charlson Comorbidity Index (CCI), American Society of Anesthesiologists status (ASA) physical status, Duke Activity Status Index (DASI), indications, procedural success, and 30-day complications (per Cotton's criteria). Results: Of 403 ERCPs, 363 (90.7%) were performed in patients ≥70 years old. Of those, 199 were aged 70–80 years (mean 77.67 ± 5.4 years) and 164 were aged 81–103 years (mean 87.36 ± 5.26 years). The ≥81 years age group had more males (120 of 164, 73.2% vs. 123 of 199, 61.8%; P = 0.022), lower DASI (14.8 vs. 25.12; P < 0.001), and higher comorbidity rate (156 of 164, 95.12% vs. 150 of 199, 75.38%; P < 0.001). Common indications and technique success rates were similar between groups. Overall complication rates did not differ significantly; post ERCP pancreatitis (PEP) was more frequent in younger than in the older group (8 of 199, 4.02% vs 2 of 164, 1.21%; P = 0.096). No 30-day ERCP-related mortality was reported in either group. Conclusions: ERCP was safe and effective in Saudi geriatric patients, including those ≥81 years, with complication rates indicating that age alone should not preclude its use when clinically indicated.

Subjects: *Elder care; *Patient safety; *T-test (Statistics)Saudi Arabia

  • Source: Saudi Journal of Gastroenterology. Nov/Dec2025, Vol. 31 Issue 6, p338-346. 9p.

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Academic Journal

Large duct primary sclerosing cholangitis with or without inflammatory bowel disease in Saudi patients Background: Primary sclerosing cholangitis (PSC) is often associated with inflammatory bowel disease (IBD). We aimed to compare the clinical presentations and outcomes of PSC in patients with and without IBD in Saudi population. Methods: The medical records of patients with PSC, diagnosed between 2009 and 2020, in a single referral center in Saudi Arabia were reviewed. Primary outcomes included liver-related clinical decompensations, while secondary outcomes encompassed hepatobiliary malignancies, liver-related mortality, and liver transplantation. Results: Among 87 patients, 52 (59.8%) had PSC-IBD and 35 (40.2%) had PSC without IBD. PSC-IBD patients were significantly younger at diagnosis (35.4 ± 13.3 vs. 43.6 ± 12.8 years, P = 0.005). Non-IBD patients exhibited higher rates of diabetes (P = 0.045), hyperlipidemia (P = 0.022), and autoimmune hepatitis (P = 0.008). While clinical presentations were similar, non-IBD patients demonstrated more frequent cytopenia from splenomegaly (31.4% vs. 5.8%, P = 0.001) and hepatic decompensation (37.1% vs. 7.7%, P = 0.001). Bilirubin (P = 0.002) and aspartate aminotransferase (P = 0.042) levels were increased in non-IBD patients, while PSC-IBD patients had higher white blood cell (P = 0.021) and platelet counts (P < 0.001). Liver biopsies were more frequently performed in non-IBD patients (45.7% vs. 19.2%, P = 0.008). Overall mortality was 12.8%, with no difference in median survival time between groups (P = 0.782). Multivariate analysis identified age (hazard ratio [HR]: 1.048, P = 0.044) and MELD-Na (HR: 1.155, P = 0.016) as independent predictors of mortality. Conclusion: In this Saudi cohort, non-IBD PSC patients were diagnosed later and presented with more comorbidities and hepatic decompensation. However, IBD status did not impact overall survival. Older age and higher MELD-Na scores at presentation were signific

Subjects: *Leukocytes; *Biopsy; *MortalitySaudi Arabia

  • Source: Saudi Journal of Gastroenterology. Nov/Dec2025, Vol. 31 Issue 6, p356-366. 11p.

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  • 1-10 of  203,021 results for ""Longitudinal method""