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The one-carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation

• Authors : Marttila, P; Bonagas, N; Chalkiadaki, C

Subjects: Medicin och hälsovetenskap

• Source: Molecular oncology. 18(9):2179-2195

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Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response

• Authors : Ramos, L; Henriksson, M; Helleday, T

Subjects: Medicin och hälsovetenskap

• Source: Cancer research. 84(1):9-16

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Deciphering the nuclear function of folate enzyme MTHFD2 in cancer: a novel role for nuclear MTHFD2 in mitosis

• Authors : Pardo Lorente, Natalia; University/Department: Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida; ...

Subjects: Folate metabolism; Mitosis; Methylation

• Source: TDX (Tesis Doctorals en Xarxa)

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Senescence Reprogramming by MTHFD2 Deficiency Facilitates Tumor Progression.

• Authors : Ping Wang¹; Zhou Fang²; Wei Pei²

• Source: Journal of Cancer. 2024, Vol. 15 Issue 20, p6545-6561. 17p.

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MTHFD2 promotes osteoclastogenesis and bone loss in rheumatoid arthritis by enhancing CKMT1-mediated oxidative phosphorylation.

• Authors : Li, Yujing¹ (AUTHOR); Cai, Minglong¹ (AUTHOR); Qin, Yi^1,2 (AUTHOR)

• Source: BMC Medicine. 2/27/2025, Vol. 23 Issue 1, p1-17. 17p.

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EP300-mediated H3 acetylation elevates MTHFD2 expression to reduce mitochondrial dysfunction in lipopolysaccharide-induced tubular epithelial cells.

• Authors : Hu, Weike¹ (AUTHOR)

• Source: Renal Failure. Dec2024, Vol. 46 Issue 2, p1-12. 12p.

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亚甲基四氢叶酸脱氢酶 2 是异质性细胞叠套结构形成的 负调控分子.

• Authors : 冯鹏飞^1,2,3; 刘辰瑜^3,4; 黄一诺^3,4

• Source: Chinese Journal of Biochemistry & Molecular Biology. Jun2024, Vol. 40 Issue 6, p819-826. 8p.

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Nuclear localization of MTHFD2 is required for correct mitosis progression

• Authors : Natalia Pardo-Lorente; Anestis Gkanogiannis; Luca Cozzuto

Subjects: Science

• Source: Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)

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The correlation between MTHFD2 and the tumor microenvironment in head and neck squamous cell carcinoma

• Authors : SHI Zhenxiang; WU Sa; CAI Weisong

Subjects: mthfd2; head and neck squamous cell carcinoma; prognosis

• Source: Yixue xinzhi zazhi, Vol 34, Iss 3, Pp 291-300 (2024)

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Selectivity analysis of diaminopyrimidine-based inhibitors of MTHFD1, MTHFD2 and MTHFD2L.

• Authors : Jha, Vibhu^1,2 (AUTHOR); Eriksson, Leif A.¹ (AUTHOR)

• Source: Scientific Reports. 9/10/2024, Vol. 14 Issue 1, p1-20. 20p.

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