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Academic Journal

cGAMP promotes inner blood-retinal barrier breakdown through P2RX7-mediated transportation into microglia.

  • Authors : Ge X; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-Sen University, Guangzhou, 510060, China.; Zhu X

Subjects: Receptors, Purinergic P2X7*/Receptors, Purinergic P2X7*/Receptors, Purinergic P2X7*/metabolism ; Microglia*/Microglia*/Microglia*/metabolism ; Microglia*/Microglia*/Microglia*/drug effects

  • Source: Journal of neuroinflammation [J Neuroinflammation] 2025 Mar 01; Vol. 22 (1), pp. 58. Date of Electronic Publication: 2025 Mar 01.Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094

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Academic Journal

Combining antimiR-25 and cGAMP Nanocomplexes Enhances Immune Responses via M2 Macrophage Reprogramming.

  • Authors : Petrovic M; Institute of Pharmaceutical Sciences of Western Switzerland (ISPSO), Faculty of Science, University of Geneva, 1206 Geneva, Switzerland.; Majchrzak OB

Subjects: MicroRNAs*/MicroRNAs*/MicroRNAs*/genetics ; Glioblastoma*/Glioblastoma*/Glioblastoma*/metabolism ; Glioblastoma*/Glioblastoma*/Glioblastoma*/immunology

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Nov 28; Vol. 25 (23). Date of Electronic Publication: 2024 Nov 28.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Homogeneous and bioluminescent biochemical and cellular assay for monitoring cGAMP and enzymes that generate and degrade cGAMP.

  • Authors : Hsiao K; Promega Corporation, 2800 Woods Hollow Road, Madison, WI, 53711, USA.; Murray NH

Subjects: Nucleotides, Cyclic*/Nucleotides, Cyclic*/Nucleotides, Cyclic*/metabolism ; Nucleotidyltransferases*/Nucleotidyltransferases*/Nucleotidyltransferases*/metabolism; Humans

  • Source: Scientific reports [Sci Rep] 2024 Dec 28; Vol. 14 (1), pp. 31165. Date of Electronic Publication: 2024 Dec 28.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

T Cell-Derived Apoptotic Extracellular Vesicles Hydrolyze cGAMP to Alleviate Radiation Enteritis via Surface Enzyme ENPP1.

  • Authors : Zhou Y; College of Life Sciences, Northwest University, Xi'an, Shaanxi, 710069, China.; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.

Subjects: Phosphoric Diester Hydrolases*/Phosphoric Diester Hydrolases*/Phosphoric Diester Hydrolases*/metabolism ; Extracellular Vesicles*/Extracellular Vesicles*/Extracellular Vesicles*/metabolism ; Enteritis*/Enteritis*/Enteritis*/metabolism

  • Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Aug; Vol. 11 (31), pp. e2401634. Date of Electronic Publication: 2024 Jun 18.Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844

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Academic Journal

Modelling and analysis of cAMP-induced mixed-mode oscillations in cortical neurons: Critical roles of HCN and M-type potassium channels.

  • Authors : Martin M; Department of Information Engineering, University of Padova, Padova, Italy.; Pedersen MG

Subjects: Potassium Channels*/Potassium Channels*/Potassium Channels*/chemistry ; Nucleotides, Cyclic*/Nucleotides, Cyclic*/Nucleotides, Cyclic*/pharmacology; Neurons

  • Source: PLoS computational biology [PLoS Comput Biol] 2024 Mar 22; Vol. 20 (3), pp. e1011559. Date of Electronic Publication: 2024 Mar 22 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Exploration of the Binding Mechanism of Cyclic Dinucleotide Analogs to Stimulating Factor Proteins and the Implications for Subsequent Analog Drug Design.

  • Authors : Yuan SW; Henan Provincial Engineering Laboratory of Insect Bio-Reactor and College of Life Science and Agricultural Engineering, Nanyang Normal University, 1638 Wolong Road, Nanyang 473061, China.; Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering, Henan Normal University, 46 Jianshe East Road, Xinxiang 453007, China.

Subjects: Nucleotides, Cyclic* ; Membrane Proteins*/Membrane Proteins*/Membrane Proteins*/metabolism; Humans

  • Source: Biomolecules [Biomolecules] 2024 Mar 14; Vol. 14 (3). Date of Electronic Publication: 2024 Mar 14.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X

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Academic Journal

Molecular mechanism of allosteric activation of the CRISPR ribonuclease Csm6 by cyclic tetra-adenylate.

  • Authors : Du L; College of Chemistry, Fuzhou University, 350108, Fuzhou, China.; Zhu Q

Subjects: Clustered Regularly Interspaced Short Palindromic Repeats* ; Ribonucleases*/Ribonucleases*/Ribonucleases*/metabolism ; Nucleotides, Cyclic*

  • Source: The EMBO journal [EMBO J] 2024 Jan; Vol. 43 (2), pp. 304-315. Date of Electronic Publication: 2023 Dec 19.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The Many Ways to Deal with STING.

  • Authors : Coderch C; Departamento de Química y Bioquímica, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28668 Boadilla del Monte, Spain.; Arranz-Herrero J

Subjects: Nucleotides, Cyclic* ; Adjuvants, Immunologic*; Animals

  • Source: International journal of molecular sciences [Int J Mol Sci] 2023 May 20; Vol. 24 (10). Date of Electronic Publication: 2023 May 20.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Enhanced Tumor Immunotherapy by Triple Amplification Effects of Nanomedicine on the STING Signaling Pathway in Dendritic Cells.

  • Authors : Wang XY; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.; Yan Y

Subjects: Dendritic Cells*/Dendritic Cells*/Dendritic Cells*/metabolism ; Dendritic Cells*/Dendritic Cells*/Dendritic Cells*/immunology ; Dendritic Cells*/Dendritic Cells*/Dendritic Cells*/drug effects

  • Source: Advanced healthcare materials [Adv Healthc Mater] 2025 Jan; Vol. 14 (2), pp. e2403143. Date of Electronic Publication: 2024 Oct 23.Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659

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Academic Journal

The cotranscriptional folding landscape for two cyclic di-nucleotide-sensing riboswitches with highly homologous aptamer domains acting either as ON- or OFF-switches.

  • Authors : Landgraf T; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt am Main, Hessen, Max-von-Laue-Str. 7 60438 Frankfurt/Main, Germany.; Völklein AE

Subjects: Nucleotides, Cyclic* ; Riboswitch*

  • Source: Nucleic acids research [Nucleic Acids Res] 2022 Jul 08; Vol. 50 (12), pp. 6639-6655.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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  • 1-10 of  1,313 results for ""Nucleotides, Cyclic""