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Academic Journal

Pyridoxic Acid as Endogenous Biomarker of Renal Organic Anion Transporter Activity: Population Variability and Mechanistic Modeling to Predict Drug-Drug Interactions.

  • Authors : Thakur A; Pharmacokinetics, Pharmacodynamics, and Metabolism Department, Pfizer Inc., Groton, Connecticut, USA.; College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA.

Subjects: Models, Biological* ; Pyridoxic Acid*/Pyridoxic Acid*/Pyridoxic Acid*/blood ; Pyridoxic Acid*/Pyridoxic Acid*/Pyridoxic Acid*/pharmacokinetics

  • Source: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2025 May; Vol. 14 (5), pp. 904-917. Date of Electronic Publication: 2025 Feb 24.Publisher: Wiley Country of Publication: United States NLM ID: 101580011 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Evaluation of Adefovir PBPK Model to Assess Biomarker-Informed OAT1 Drug-Drug Interaction and Effect of Chronic Kidney Disease.

  • Authors : Tan SPF; Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, Manchester, UK.; Wu H

Subjects: Adenine*/Adenine*/Adenine*/analogs & derivatives ; Adenine*/Adenine*/Adenine*/pharmacokinetics ; Adenine*/Adenine*/Adenine*/administration & dosage

  • Source: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2025 May; Vol. 14 (5), pp. 964-974. Date of Electronic Publication: 2025 Mar 03.Publisher: Wiley Country of Publication: United States NLM ID: 101580011 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

OAT3 Participates in Drug-Drug Interaction between Bentysrepinine and Entecavir through Interactions with M8-A Metabolite of Bentysrepinine-In Rats and Humans In Vitro.

  • Authors : Zhang A; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.; State Key Laboratory of Functions and Applications of Medicinal Plants, Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang 550025, China.

Subjects: Organic Anion Transporters, Sodium-Independent*/Organic Anion Transporters, Sodium-Independent*/Organic Anion Transporters, Sodium-Independent*/metabolism ; Organic Anion Transport Protein 1*/Organic Anion Transport Protein 1*/Organic Anion Transport Protein 1*/metabolism; Humans

  • Source: Molecules (Basel, Switzerland) [Molecules] 2023 Feb 20; Vol. 28 (4). Date of Electronic Publication: 2023 Feb 20.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Hederagenin's uric acid-lowering effects in hyperuricemic mice: Mechanistic insights from molecular docking and in vivo analysis.

  • Authors : Chen P; School of Clinical Medicine, Jiamusi University, Jiamusi, China.; Tian YN

Subjects: Hyperuricemia*/Hyperuricemia*/Hyperuricemia*/drug therapy ; Hyperuricemia*/Hyperuricemia*/Hyperuricemia*/metabolism ; Hyperuricemia*/Hyperuricemia*/Hyperuricemia*/blood

  • Source: PloS one [PLoS One] 2025 Jun 24; Vol. 20 (6), pp. e0326317. Date of Electronic Publication: 2025 Jun 24 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Drug transporters OAT1 and OAT3 have specific effects on multiple organs and gut microbiome as revealed by contextualized metabolic network reconstructions.

  • Authors : Jamshidi N; Department of Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, USA. .; Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA, USA. .

Subjects: Gastrointestinal Microbiome* ; Organic Anion Transport Protein 1*/Organic Anion Transport Protein 1*/Organic Anion Transport Protein 1*/metabolism ; Organic Anion Transporters, Sodium-Independent*/Organic Anion Transporters, Sodium-Independent*/Organic Anion Transporters, Sodium-Independent*/metabolism

  • Source: Scientific reports [Sci Rep] 2022 Oct 31; Vol. 12 (1), pp. 18308. Date of Electronic Publication: 2022 Oct 31.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Hypouricemic agents reduce indoxyl sulfate excretion by inhibiting the renal transporters OAT1/3 and ABCG2.

  • Authors : Taniguchi T; Research Laboratories 2, Fuji Yakuhin Co., Ltd., 636-1, Iida-Shinden, Nishi-ku, Saitama, Japan. .; Omura K

Subjects: Acute Kidney Injury*/Acute Kidney Injury*/Acute Kidney Injury*/blood ; Acute Kidney Injury*/Acute Kidney Injury*/Acute Kidney Injury*/chemically induced ; Acute Kidney Injury*/Acute Kidney Injury*/Acute Kidney Injury*/drug therapy

  • Source: Scientific reports [Sci Rep] 2021 Mar 31; Vol. 11 (1), pp. 7232. Date of Electronic Publication: 2021 Mar 31.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Genetic Diversity in Drug Transporters: Impact in African Populations.

Subjects: Pharmacogenomic Variants*; Black People/Black People/Black People/*genetics ; Drug-Related Side Effects and Adverse Reactions/Drug-Related Side Effects and Adverse Reactions/Drug-Related Side Effects and Adverse Reactions/*genetics

  • Source: Clinical and translational science [Clin Transl Sci] 2020 Sep; Vol. 13 (5), pp. 848-860. Date of Electronic Publication: 2020 Mar 31.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Nano Ellagic Acid Counteracts Cisplatin-Induced Upregulation in OAT1 and OAT3: A Possible Nephroprotection Mechanism.

  • Authors : Neamatallah T; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; El-Shitany N

Subjects: Cisplatin/Cisplatin/Cisplatin/*adverse effects ; Ellagic Acid/Ellagic Acid/Ellagic Acid/*pharmacology ; Kidney/Kidney/Kidney/*drug effects

  • Source: Molecules (Basel, Switzerland) [Molecules] 2020 Jul 02; Vol. 25 (13). Date of Electronic Publication: 2020 Jul 02.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Andrographolide is neither a human organic anion transporter 1 (hOAT1) substrate nor inhibitor.

  • Authors : Chong YM; a Malaysian Institute of Pharmaceuticals and Nutraceuticals, NIBM , Ministry of Science Technology and Innovation (MOSTI) , Pulau Pinang , Malaysia.; Kaur G

Subjects: Diterpenes/Diterpenes/Diterpenes/*pharmacology ; Organic Anion Transport Protein 1/Organic Anion Transport Protein 1/Organic Anion Transport Protein 1/*antagonists & inhibitors; Animals

  • Source: Journal of Asian natural products research [J Asian Nat Prod Res] 2019 Aug; Vol. 21 (8), pp. 754-771. Date of Electronic Publication: 2019 Jan 03.Publisher: Informa Healthcare Country of Publication: England NLM ID: 100888334 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Phyllanthi Fructus ameliorates hyperuricemia and kidney injure via inhibiting uric acid synthesis, modulating urate transporters, and alleviating inflammation.

  • Authors : Liang S; The First Affiliated Hospital of Shenzhen University, Shenzhen, 518020, China.; Xu D

Subjects: Hyperuricemia*/Hyperuricemia*/Hyperuricemia*/drug therapy ; Hyperuricemia*/Hyperuricemia*/Hyperuricemia*/metabolism ; Uric Acid*/Uric Acid*/Uric Acid*/metabolism

  • Source: Scientific reports [Sci Rep] 2024 Nov 11; Vol. 14 (1), pp. 27605. Date of Electronic Publication: 2024 Nov 11.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  185 results for ""Organic Anion Transport Protein 1""