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Phase Separation of FUS with Poly(ADP-ribosyl)ated PARP1 Is Controlled by Polyamines, Divalent Metal Cations, and Poly(ADP-ribose) Structure.

• Authors : Sukhanova, Maria V.¹ (AUTHOR) ; Anarbaev, Rashid O.¹ (AUTHOR) ; Naumenko, Konstantin N.¹ (AUTHOR)

Subjects: *ATOMIC force microscopy; *PROTEIN stability; *FLUORESCENCE microscopy

• Source: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 22, p12445. 19p.

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Intracellular accumulation of free cholesterol in macrophages triggers a PARP1 response to DNA damage and PARP1 impairs lipopolysaccharide-induced inflammatory response.

• Authors : Ting, Kenneth K.Y.^1,2 (AUTHOR); Ibrahim, Hisham M.^2,3 (AUTHOR); Gulati, Nitya² (AUTHOR)

Subjects: *FOAM cells; *GENE expression; *REACTIVE oxygen species

• Source: PLoS ONE. 3/5/2025, Vol. 20 Issue 3, p1-22. 22p.

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Aminomethylmorpholino Nucleosides as Novel Inhibitors of PARP1 and PARP2: Experimental and Molecular Modeling Analyses of Their Selectivity and Mechanism of Action.

• Authors : Chernyshova, Irina¹ (AUTHOR) ; Vasil'eva, Inna¹ (AUTHOR) ; Moor, Nina¹ (AUTHOR)

Subjects: *DNA repair; *DNA damage; *MOLECULAR docking

• Source: International Journal of Molecular Sciences. Dec2024, Vol. 25 Issue 23, p12526. 18p.

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A First-in-human Study of PARP1 Selective Inhibitor, IMP1734, in Participants With Advanced Solid Tumors

• Authors : Impact Therapeutics, Inc.

• Source: A First-in-human, Phase 1/2, Open-label, Multi-center, Dose-escalation, Dose-optimization, and Dose-expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and

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Exploring the role of PARP1 inhibition in enhancing antibody–drug conjugate therapy for acute leukemias: insights from DNA damage response pathway interactions

• Authors : Andrea Ghelli Luserna di Rorà; Mouna Jandoubi; Antonella Padella

Subjects: Antibody–drug conjugates; PARP1 inhibition; DNA damage response pathway

• Source: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-18 (2024)

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Integrating machine learning driven virtual screening and molecular dynamics simulations to identify potential inhibitors targeting PARP1 against prostate cancer.

• Authors : Aldakheel, Fahad M.¹ (AUTHOR) ; Alduraywish, Shatha A.² (AUTHOR); Dabwan, Khaled H.¹ (AUTHOR)

• Source: Scientific Reports. 4/14/2025, Vol. 15 Issue 1, p1-19. 19p.

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XRCC1 mediates PARP1- and PAR-dependent recruitment of PARP2 to DNA damage sites.

• Authors : Lin, Xiaohui¹ (AUTHOR); Leung, Kay Sze Karina² (AUTHOR); Wolfe, Kaitlynn F² (AUTHOR)

Subjects: *SINGLE-strand DNA breaks; *DNA damage; *DNA repair

• Source: Nucleic Acids Research. 2/28/2025, Vol. 53 Issue 4, p1-16. 16p.

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Transcriptional regulation mechanism of PARP1 and its application in disease treatment.

• Authors : Lu, Yu^1,2 (AUTHOR); Fu, Wenliang¹ (AUTHOR); Xing, Weiwei¹ (AUTHOR)

• Source: Epigenetics & Chromatin. 8/8/2024, Vol. 17 Issue 1, p1-11. 11p.

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SERBP1 interacts with PARP1 and is present in PARylation-dependent protein complexes regulating splicing, cell division, and ribosome biogenesis

• Authors : Kira Breunig; Xuifen Lei; Mauro Montalbano

Subjects: SERBP1; PARP1; RNA binding protein

• Source: eLife, Vol 13 (2025)

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ExermiR‐129‐3p Enhances Muscle Function by Improving Mitochondrial Activity Through PARP1 Inhibition

• Authors : Yeo Jin Shin; Jae Won Yang; Heeyeon Jeong

Subjects: exercise mimic; exermiR; microRNA

• Source: Journal of Cachexia, Sarcopenia and Muscle, Vol 16, Iss 2, Pp n/a-n/a (2025)

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