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A plant DNA virus replicates in the salivary glands of its insect vector via recruitment of host DNA synthesis machinery

Authors : Xiao-Wei Wang; Ya-Zhou He; Yin-Quan Liu

Subjects: 0106 biological sciences; 0301 basic medicine; replication

Source: Proceedings of the National Academy of Sciences of the United States of America

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Force and phosphate release from Arp2/3 complex promote dissociation of actin filament branches

Authors : Nandan G Pandit; Edwin W Taylor; Eric M Johnson-Chavarria

Subjects: Glia Maturation Factor; Microfluidics; Motility

Source: Proc Natl Acad Sci U S A

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Evaluation of musculoskeletal phenotype of the G608G progeria mouse model with lonafarnib, pravastatin, and zoledronic acid as treatment groups

Authors : Wayne A. Cabral; Maria B. Cubria; Ara Nazarian

Subjects: Aging; Pathology; medicine.medical_specialty

Source: Proc Natl Acad Sci U S A

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Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling

Authors : D. Eric Dollins; Samuel G. Gattis; Peter C. Fridy

Subjects: Cell signaling; inositol phosphate; kinase

Source: Proceedings of the National Academy of Sciences of the United States of America

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Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia

Authors : Abinaya Rajendran; Hema P Bagul; Babukrishna Maniyadath

Subjects: Male; Aging; Glycosylation

Source: Proc Natl Acad Sci U S A

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NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin decondensation and nuclear envelope rupture

Authors : Robert D. Goldman; Anne E. Goldman; Rong Qiu

Subjects: 0303 health sciences; Multidisciplinary; biology

Source: Proceedings of the National Academy of Sciences of the United States of America

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Endothelial sphingosine 1-phosphate receptors promote vascular normalization and antitumor therapy

Authors : Andreane Cartier; Timothy Hla; Catherine H. Liu

Subjects: Medical Sciences; Angiogenesis; Antineoplastic Agents

Source: Proceedings of the National Academy of Sciences of the United States of America

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Selectivity filter modalities and rapid inactivation of the hERG1 channel

Authors : Sergei Y. Noskov; Williams E. Miranda; Colleen E. Clancy

Subjects: Protein Structure; Secondary; ERG1 Potassium Channel

Source: Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 6Proc Natl Acad Sci U S A

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GABA-mediated tonic inhibition differentially modulates gain in functional subtypes of cortical interneurons

Authors : Alexander Bryson; Christopher A. Reid; Sean Hill

Subjects: Patch-Clamp Techniques; membrane-properties; Interneuron

Source: Proc Natl Acad Sci U S A

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Pressure sensing through Piezo channels controls whether cells migrate with blebs or pseudopods

Authors : Robert R. Kay; Matthieu Piel; David Traynor ...

Subjects: Cytoplasm; blebbing; cell migration

Source: Proceedings of the National Academy of Sciences of the United States of AmericaProceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences,

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