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磷酸二酯酶-4抑制剂治疗掌跖脓疱病的研究进展.

• Authors : 姚心怡¹; 高文丽¹; 李娟¹

• Source: Journal of Diagnosis & Therapy on Dermato-venereology. Nov2024, Vol. 31 Issue 11, p789-794. 6p.

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Differential effects of two phosphodiesterase 4 inhibitors against lipopolysaccharide-induced neuroinflammation in mice.

• Authors : Kang DH; Data Convergence Drug Research Center, Therapeutics & Biotechnology Division, Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon, 34114, Korea.; College of Pharmacy, Chungnam National University, Daejeon, Korea.

Subjects: Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/pharmacology; Mice ; Animals

• Source: BMC neuroscience [BMC Neurosci] 2023 Jul 31; Vol. 24 (1), pp. 39. Date of Electronic Publication: 2023 Jul 31.Publisher: BioMed Central Country of Publication: England NLM ID: 100966986 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2202

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Molecular Properties of Phosphodiesterase 4 and Its Inhibition by Roflumilast and Cilomilast.

• Authors : Kwak HJ; Department of Bio and Fermentation Convergence Technology, Kookmin University, Seoul 02707, Republic of Korea.; Nam KH

Subjects: Cyclopropanes*/Cyclopropanes*/Cyclopropanes*/pharmacology ; Cyclopropanes*/Cyclopropanes*/Cyclopropanes*/chemistry ; Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/chemistry

• Source: Molecules (Basel, Switzerland) [Molecules] 2025 Feb 04; Vol. 30 (3). Date of Electronic Publication: 2025 Feb 04.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Phosphodiesterase 4 Inhibition in Neuropsychiatric Disorders Associated with Alzheimer's Disease.

• Authors : Chen J; Department of Anesthesiology, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA.; Zhu Z

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/drug therapy ; Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/therapeutic use ; Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/pharmacology

• Source: Cells [Cells] 2025 Jan 22; Vol. 14 (3). Date of Electronic Publication: 2025 Jan 22.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Insilico discovery of novel Phosphodiesterase 4 (PDE4) inhibitors for the treatment of psoriasis: Insights from computer aided drug design approaches.

• Authors : Alanzi AR; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.; Alsalhi MS

Subjects: Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/chemistry ; Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/therapeutic use ; Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/pharmacology

• Source: PloS one [PLoS One] 2024 Nov 13; Vol. 19 (11), pp. e0305934. Date of Electronic Publication: 2024 Nov 13 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Application of Topical Phosphodiesterase 4 Inhibitors in Mild to Moderate Atopic Dermatitis

• Authors : Maria Elsa, Maria Elsa; Marsela, Marsela

Subjects: Topical Phosphodiesterase 4 Inhibitors; Mild to Moderate Atopic Dermatitis; info:eu-repo/semantics/article

• Source: The International Journal of Medical Science and Health Research; Vol. 5 No. 4 (2024): The International Journal of Medical Science and Health Research; 1-11; 3048-1368;

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Safety, pharmacokinetics, and pharmacodynamics of ART-648, a PDE4 inhibitor in healthy subjects: A randomized, placebo-controlled phase I study.

• Authors : Tanaka A; Department of Clinical Pharmacology and Therapeutics, Faculty of Medicine, Oita University, Oita, Japan.; ARTham Therapeutics Inc., Yokohama, Japan.

Subjects: Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/pharmacokinetics ; Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/administration & dosage ; Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/adverse effects

• Source: Clinical and translational science [Clin Transl Sci] 2024 Oct; Vol. 17 (10), pp. e70024.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN:

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Dual Inhibition of Phosphodiesterase 3 and 4 Enzymes by Ensifentrine Protects against MRSA-Induced Lung Endothelial and Epithelial Dysfunction.

• Authors : Al Matni MY; Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois Chicago, Chicago, IL 60612, USA.; Meliton L

Subjects: Methicillin-Resistant Staphylococcus aureus*/Methicillin-Resistant Staphylococcus aureus*/Methicillin-Resistant Staphylococcus aureus*/drug effects ; Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/pharmacology ; Endothelial Cells*/Endothelial Cells*/Endothelial Cells*/drug effects

• Source: Cells [Cells] 2024 Oct 23; Vol. 13 (21). Date of Electronic Publication: 2024 Oct 23.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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PDE4D: A Multipurpose Pharmacological Target.

• Authors : Lusardi M; Department of Pharmacy (DIFAR), University of Genoa, Viale Benedetto XV 3, 16132 Genova, Italy.; Rapetti F

Subjects: Cyclic Nucleotide Phosphodiesterases, Type 4*/Cyclic Nucleotide Phosphodiesterases, Type 4*/Cyclic Nucleotide Phosphodiesterases, Type 4*/metabolism ; Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/pharmacology ; Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/Phosphodiesterase 4 Inhibitors*/therapeutic use

• Source: International journal of molecular sciences [Int J Mol Sci] 2024 Jul 24; Vol. 25 (15). Date of Electronic Publication: 2024 Jul 24.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Early Inhibition of Phosphodiesterase 4B (PDE4B) Instills Cognitive Resilience in APPswe/PS1dE9 Mice.

• Authors : Rombaut B; Department of Neuroscience, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, 3500 Hasselt, Belgium.; Department Psychiatry and Neuropsychology, Mental Health and Neuroscience Institute (MHeNs), Division Translational Neuroscience, Maastricht University, 6229 ER Maastricht, The Netherlands.

Subjects: Cyclic Nucleotide Phosphodiesterases, Type 4*/Cyclic Nucleotide Phosphodiesterases, Type 4*/Cyclic Nucleotide Phosphodiesterases, Type 4*/metabolism ; Mice, Transgenic* ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/drug therapy

• Source: Cells [Cells] 2024 Jun 08; Vol. 13 (12). Date of Electronic Publication: 2024 Jun 08.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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