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Synthesis, Pharmacological Evaluation, and Molecular Modeling of Lappaconitine-1,5-Benzodiazepine Hybrids.

• Authors : Cheremnykh KP; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentjev Avenue 9, 630090 Novosibirsk, Russia.; Bryzgalov AO

Subjects: Aconitine*/Aconitine*/Aconitine*/analogs & derivatives ; Aconitine*/Aconitine*/Aconitine*/chemical synthesis ; Aconitine*/Aconitine*/Aconitine*/pharmacology

• Source: Molecules (Basel, Switzerland) [Molecules] 2023 May 22; Vol. 28 (10). Date of Electronic Publication: 2023 May 22.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Study of Amiloride Binding to Human Serum Albumin: Insights from Thermodynamic, Spectroscopic, and Molecular Docking Investigations.

• Authors : Rahman, Safikur¹ (AUTHOR) ; Iram, Sana² (AUTHOR) ; Rehman, Md Tabish³ (AUTHOR)

Subjects: *SERUM albumin; *MOLECULAR docking; *AMILORIDE

• Source: Molecules. Dec2023, Vol. 28 Issue 23, p7688. 17p.

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Blockers of Skeletal Muscle Na v 1.4 Channels: From Therapy of Myotonic Syndrome to Molecular Determinants of Pharmacological Action and Back.

• Authors : De Bellis M; Section of Pharmacology, Department of Pharmacy-Drug Sciences, University of Bari 'Aldo Moro', 70125 Bari, Italy.; Boccanegra B

Subjects: Mexiletine*/Mexiletine*/Mexiletine*/pharmacology ; Mexiletine*/Mexiletine*/Mexiletine*/therapeutic use ; Myotonia*/Myotonia*/Myotonia*/drug therapy

• Source: International journal of molecular sciences [Int J Mol Sci] 2023 Jan 03; Vol. 24 (1). Date of Electronic Publication: 2023 Jan 03.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Tuning Sodium Channel Blockers to the Near-Atomic Level.

• Authors : Eyal, Sara¹ (AUTHOR)

• Source: Epilepsy Currents. Mar-Apr2024, Vol. 24 Issue 2, p123-125. 3p.

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Sodium Channel β Subunits-An Additional Element in Animal Tetrodotoxin Resistance?

• Authors : Seneci L; Adaptive Biotoxicology Lab, School of the Environment, The University of Queensland, St Lucia, QLD 4067, Australia.; Mikheyev AS

Subjects: Voltage-Gated Sodium Channels*/Voltage-Gated Sodium Channels*/Voltage-Gated Sodium Channels*/genetics; Animals ; Tetrodotoxin/Tetrodotoxin/Tetrodotoxin/pharmacology

• Source: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 25; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 25.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Genetic Background of Epilepsy and Antiepileptic Treatments.

• Authors : Borowicz-Reutt, Kinga¹ (AUTHOR) ; Czernia, Julia¹ (AUTHOR); Krawczyk, Marlena¹ (AUTHOR)

Subjects: *EPILEPSY; *SODIUM channel blockers; *GENETIC variation

• Source: International Journal of Molecular Sciences. Nov2023, Vol. 24 Issue 22, p16280. 20p.

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µ-Conotoxins Targeting the Human Voltage-Gated Sodium Channel Subtype Na V 1.7.

• Authors : McMahon KL; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.; Tran HNT

Subjects: Conotoxins*/Conotoxins*/Conotoxins*/chemistry ; Conotoxins*/Conotoxins*/Conotoxins*/pharmacology ; Voltage-Gated Sodium Channel Blockers*/Voltage-Gated Sodium Channel Blockers*/Voltage-Gated Sodium Channel Blockers*/chemistry

• Source: Toxins [Toxins (Basel)] 2022 Aug 30; Vol. 14 (9). Date of Electronic Publication: 2022 Aug 30.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101530765 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6651

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An Overview of the Anatomical Distribution of Tetrodotoxin in Animals.

• Authors : Melnikova DI; A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, 690041 Vladivostok, Russia.; Magarlamov TY

Subjects: Ecosystem* ; Sodium Channel Blockers*/Sodium Channel Blockers*/Sodium Channel Blockers*/pharmacology; Animals

• Source: Toxins [Toxins (Basel)] 2022 Aug 22; Vol. 14 (8). Date of Electronic Publication: 2022 Aug 22.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101530765 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6651

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A concise synthesis of tetrodotoxin.

• Authors : Konrad DB; Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377 Munich, Germany.; Rühmann KP

Subjects: Tetrodotoxin*/Tetrodotoxin*/Tetrodotoxin*/chemical synthesis ; Voltage-Gated Sodium Channel Blockers*/Voltage-Gated Sodium Channel Blockers*/Voltage-Gated Sodium Channel Blockers*/chemical synthesis; Catalysis

• Source: Science (New York, N.Y.) [Science] 2022 Jul 22; Vol. 377 (6604), pp. 411-415. Date of Electronic Publication: 2022 Jul 21.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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Effect of Linker Elongation on the VGSC Affinity and Anticonvulsant Activity among 4-Alkyl-5-aryl-1,2,4-triazole-3-thione Derivatives.

• Authors : Paruch, Kinga¹ (AUTHOR) ; Kaproń, Barbara² (AUTHOR) ; Łuszczki, Jarogniew J.³ (AUTHOR)

Subjects: *PILOCARPINE; *SODIUM channels; *RADIOLIGAND assay

• Source: Molecules. Jul2023, Vol. 28 Issue 13, p5287. 14p.

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