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Academic Journal

Dysregulated Sialylation in Cancer: From Immunosuppressive Microenvironment to Siglec-Targeted Therapeutics.

  • Authors : Zhang Y; Key Laboratory of Analytical Technology and Detection of Yan'an, College of Chemistry and Chemical Engineering, Yan'an University, Yan'an 716000, China.; Gao Z

Subjects: Neoplasms*/Neoplasms*/Neoplasms*/metabolism ; Neoplasms*/Neoplasms*/Neoplasms*/immunology ; Neoplasms*/Neoplasms*/Neoplasms*/therapy

  • Source: Biomolecules [Biomolecules] 2025 Sep 27; Vol. 15 (10). Date of Electronic Publication: 2025 Sep 27.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X

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Academic Journal

The female reproductive tract contains multiple innate sialic acid-binding immunoglobulin-like lectins (Siglecs) that facilitate sperm survival

Subjects: Reproductive Medicine; Biochemistry and Cell Biology; Biomedical and Clinical Sciences

  • Source: Journal of Biological Chemistry. 294(31)

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Academic Journal

Chemical and Enzymatic Synthesis of DisialylGb5 and Other Sialosides for Glycan Array Assembly and Evaluation of Siglec-Mediated Immune Checkpoint Inhibition.

  • Authors : Liao KS; Genomics Research Center, Academia Sinica, Taipei 115, Taiwan.; Zhou Y

Subjects: Polysaccharides*/Polysaccharides*/Polysaccharides*/chemistry ; Immune Checkpoint Inhibitors*/Immune Checkpoint Inhibitors*/Immune Checkpoint Inhibitors*/pharmacology ; Immune Checkpoint Inhibitors*/Immune Checkpoint Inhibitors*/Immune Checkpoint Inhibitors*/chemistry

  • Source: Molecules (Basel, Switzerland) [Molecules] 2025 May 22; Vol. 30 (11). Date of Electronic Publication: 2025 May 22.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Proximity Labeling and Genetic Screening Reveal that DSG2 is a Counter Receptor of Siglec-9 and Suppresses Macrophage Phagocytosis.

  • Authors : Wu Y; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.; You Y

Subjects: Macrophages*/Macrophages*/Macrophages*/metabolism ; Macrophages*/Macrophages*/Macrophages*/immunology ; Phagocytosis*/Phagocytosis*/Phagocytosis*/genetics

  • Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Mar; Vol. 12 (9), pp. e2406654. Date of Electronic Publication: 2025 Jan 15.Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844

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Academic Journal

Anti-Tumor Activities of Anti-Siglec-15 Chimeric Heavy-Chain Antibodies.

  • Authors : Cheng K; Laboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Beijing 100081, China.; College of Public Health, Zhengzhou University, Zhengzhou 450001, China.

Subjects: Immunoglobulin Heavy Chains*/Immunoglobulin Heavy Chains*/Immunoglobulin Heavy Chains*/immunology ; Immunoglobulin Heavy Chains*/Immunoglobulin Heavy Chains*/Immunoglobulin Heavy Chains*/genetics ; Immunoglobulin Heavy Chains*/Immunoglobulin Heavy Chains*/Immunoglobulin Heavy Chains*/pharmacology

  • Source: International journal of molecular sciences [Int J Mol Sci] 2025 May 24; Vol. 26 (11). Date of Electronic Publication: 2025 May 24.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Sialylated glycoproteins suppress immune cell killing by binding to Siglec-7 and Siglec-9 in prostate cancer

Subjects: Biomedical and Clinical Sciences; Oncology and Carcinogenesis; Immunology

  • Source: Journal of Clinical Investigation. 134(24)

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Academic Journal

Targeting Recipient Dendritic Cells with Sialic Acid-Modified Donor Alloantigen Prolongs Skin Transplant Survival.

  • Authors : Sen M; School of Health, Sport and Bioscience, University of East London, Water Lane, London E15 4LZ, UK.; Peng Q

Subjects: Dendritic Cells*/Dendritic Cells*/Dendritic Cells*/immunology ; Dendritic Cells*/Dendritic Cells*/Dendritic Cells*/metabolism ; Skin Transplantation*/Skin Transplantation*/Skin Transplantation*/methods

  • Source: International journal of molecular sciences [Int J Mol Sci] 2025 Jun 26; Vol. 26 (13). Date of Electronic Publication: 2025 Jun 26.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Recent progress in targeting the sialylated glycan-SIGLEC axis in cancer immunotherapy.

  • Authors : Yu Y; Department of General Surgery of Ruijin Hospital, Shanghai Institute of Digestive Surgery, and Shanghai Key Laboratory for Gastric Neoplasms, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.; Peng W

Subjects: Sialic Acid Binding Immunoglobulin-like Lectins* ; Neoplasms*/Neoplasms*/Neoplasms*/drug therapy; Humans

  • Source: Cancer biology & medicine [Cancer Biol Med] 2023 May 03; Vol. 20 (5).Publisher: Chinese Anti-Cancer Association Country of Publication: China NLM ID: 101588850 Publication Model: Print Cited Medium: Internet ISSN:

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A pan-cancer blueprint of genomics alterations and transcriptional regulation of Siglecs, and implications in prognosis and immunotherapy responsiveness.

  • Authors : Mei S; Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, MOE Key Laboratory of Major Diseases in Children; Rare Disease Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Subjects: Sialic Acid Binding Immunoglobulin-like Lectins* ; Neoplasms*/Neoplasms*/Neoplasms*/genetics ; Neoplasms*/Neoplasms*/Neoplasms*/therapy

  • Source: Clinical and translational medicine [Clin Transl Med] 2023 May; Vol. 13 (5), pp. e1262.Publisher: Wiley Country of Publication: United States NLM ID: 101597971 Publication Model: Print Cited Medium: Internet ISSN: 2001-1326

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Academic Journal

CD33 as a leukocyte-associated marker expressed on human spermatozoa.

  • Authors : Sereshki N; Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.; Rafiee M

Subjects: Antigens, CD* ; Sialic Acid Binding Immunoglobulin-like Lectins*/Sialic Acid Binding Immunoglobulin-like Lectins*/Sialic Acid Binding Immunoglobulin-like Lectins*/metabolism; Male

  • Source: BMC research notes [BMC Res Notes] 2023 Apr 20; Vol. 16 (1), pp. 57. Date of Electronic Publication: 2023 Apr 20.Publisher: Biomed Central Country of Publication: England NLM ID: 101462768 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-0500

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  • 1-10 of  586 results for ""Sialic Acid Binding Immunoglobulin-like Lectins""