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Key virulence factors responsible for differences in pathogenicity between clinically proven live-attenuated Japanese encephalitis vaccine SA14-14-2 and its pre-attenuated highly virulent parent SA14.

• Authors : Song, Byung-Hak¹ (AUTHOR); Yun, Sang-Im¹ (AUTHOR); Goldhardt, Joseph L.¹ (AUTHOR)

• Source: PLoS Pathogens. 1/7/2025, Vol. 21 Issue 1, p1-43. 43p.

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A non-structural protein 1 substitution of dengue virus enhances viral replication by interfering with the antiviral signaling pathway.

• Authors : Hee JR; Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, No.1, University Road, Tainan, 701, Taiwan.; Cheng D

Subjects: Dengue Virus*/Dengue Virus*/Dengue Virus*/genetics ; Dengue Virus*/Dengue Virus*/Dengue Virus*/physiology ; Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/genetics

• Source: Journal of biomedical science [J Biomed Sci] 2025 Feb 20; Vol. 32 (1), pp. 25. Date of Electronic Publication: 2025 Feb 20.Publisher: BioMed Central Country of Publication: England NLM ID: 9421567 Publication Model: Electronic Cited Medium: Internet ISSN: 1423-0127

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Attenuation of Chikungunya Virus by a Single Amino Acid Substitution in the nsP1 Component of a Non-Structural Polyprotein.

• Authors : Chamberlain J; UK Health Security Agency (UK), Porton Down, Salisbury SP4 0JG, UK.; Dowall SD

Subjects: Chikungunya virus*/Chikungunya virus*/Chikungunya virus*/genetics ; Chikungunya virus*/Chikungunya virus*/Chikungunya virus*/pathogenicity ; Amino Acid Substitution*

• Source: Viruses [Viruses] 2025 Feb 18; Vol. 17 (2). Date of Electronic Publication: 2025 Feb 18.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915

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A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and selects for interferon-susceptible mutant viruses.

• Authors : Van Loy B; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.; Pujol E

Subjects: Virus Replication*/Virus Replication*/Virus Replication*/drug effects ; SARS-CoV-2*/SARS-CoV-2*/SARS-CoV-2*/drug effects ; Endoribonucleases*/Endoribonucleases*/Endoribonucleases*/metabolism

• Source: PLoS pathogens [PLoS Pathog] 2025 Feb 11; Vol. 21 (2), pp. e1012571. Date of Electronic Publication: 2025 Feb 11 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet

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Avermectins Inhibit Replication of Parvovirus B19 by Disrupting the Interaction Between Importin α and Non-Structural Protein 1.

• Authors : Alvisi G; Department of Molecular Medicine, University of Padova, 35121 Padova, Italy.; Manaresi E

Subjects: Ivermectin*/Ivermectin*/Ivermectin*/pharmacology ; Ivermectin*/Ivermectin*/Ivermectin*/analogs & derivatives ; Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/metabolism

• Source: Viruses [Viruses] 2025 Feb 03; Vol. 17 (2). Date of Electronic Publication: 2025 Feb 03.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915

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TRIM38 Inhibits Zika Virus by Upregulating RIG-I/MDA5 Pathway and Promoting Ubiquitin-Mediated Degradation of Viral NS3 Protein.

• Authors : He J; Institute of Basic Medicine, North Sichuan Medical College, Nanchong 637100, China.; Kuang Y

Subjects: Zika Virus*/Zika Virus*/Zika Virus*/physiology ; Zika Virus*/Zika Virus*/Zika Virus*/genetics ; DEAD Box Protein 58*/DEAD Box Protein 58*/DEAD Box Protein 58*/metabolism

• Source: Viruses [Viruses] 2025 Jan 30; Vol. 17 (2). Date of Electronic Publication: 2025 Jan 30.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915

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The Chikungunya Virus nsP3 Macro Domain Inhibits Activation of the NF-κB Pathway.

• Authors : Roberts GC; School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.; Stonehouse NJ

Subjects: Chikungunya virus*/Chikungunya virus*/Chikungunya virus*/genetics ; Chikungunya virus*/Chikungunya virus*/Chikungunya virus*/physiology ; Chikungunya virus*/Chikungunya virus*/Chikungunya virus*/metabolism

• Source: Viruses [Viruses] 2025 Jan 29; Vol. 17 (2). Date of Electronic Publication: 2025 Jan 29.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915

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The Japanese encephalitis virus NS1' protein facilitates virus infection in mosquitoes.

• Authors : Liu Y; Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.; Huang Y

Subjects: Encephalitis Virus, Japanese*/Encephalitis Virus, Japanese*/Encephalitis Virus, Japanese*/physiology ; Encephalitis Virus, Japanese*/Encephalitis Virus, Japanese*/Encephalitis Virus, Japanese*/genetics ; Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/metabolism

• Source: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2025 Jan 27; Vol. 19 (1), pp. e0012823. Date of Electronic Publication: 2025 Jan 27 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet

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Influenza A virus NS2 protein acts on vRNA-resident polymerase to drive the transcription to replication switch.

• Authors : Zhang L; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.; Department of Infectious Diseases, Shenzhen Children's Hospital, Shenzhen, 518026, China.

Subjects: Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/metabolism ; Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/Viral Nonstructural Proteins*/genetics ; Virus Replication*/Virus Replication*/Virus Replication*/genetics

• Source: Nucleic acids research [Nucleic Acids Res] 2025 Jan 24; Vol. 53 (3).Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Computational design of multi-epitope vaccine against Hepatitis C Virus infection using immunoinformatics techniques.

• Authors : Zubair S; Department of Biosciences, COMSATS University Islamabad (CUI), Islamabad, Pakistan.; Parvaiz F

Subjects: Hepacivirus*/Hepacivirus*/Hepacivirus*/immunology ; Hepatitis C*/Hepatitis C*/Hepatitis C*/prevention & control ; Hepatitis C*/Hepatitis C*/Hepatitis C*/immunology

• Source: PloS one [PLoS One] 2025 Jan 24; Vol. 20 (1), pp. e0317520. Date of Electronic Publication: 2025 Jan 24 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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