Search Results

Biology and Development of DNA-Targeted Drugs, Focusing on Synthetic Lethality, DNA Repair, and Epigenetic Modifications for Cancer: A Review.

• Authors : Watanabe K; Department of Medicine, School of Medicine, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan.; Seki N

Subjects: Synthetic Lethal Mutations* ; Neoplasms*/Neoplasms*/Neoplasms*/drug therapy ; Neoplasms*/Neoplasms*/Neoplasms*/genetics

• Source: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 06; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 06.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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SLKB: synthetic lethality knowledge base.

• Authors : Gökbağ B; Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.; Tang S

Subjects: Knowledge Bases* ; Synthetic Lethal Mutations*; Humans

• Source: Nucleic acids research [Nucleic Acids Res] 2024 Jan 05; Vol. 52 (D1), pp. D1418-D1428.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Transcriptional control of a stem cell factor nucleostemin in liver regeneration and aging.

• Authors : Liu, Xiaoqin^1,2 (AUTHOR); Wang, Junying¹ (AUTHOR); Li, Fang¹ (AUTHOR)

• Source: PLoS ONE. 9/11/2024, Vol. 19 Issue 9, p1-18. 18p.

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Synthetic lethality of combined ULK1 defection and p53 restoration induce pyroptosis by directly upregulating GSDME transcription and cleavage activation through ROS/NLRP3 signaling.

• Authors : Chen, Wei^1,2,3,4 (AUTHOR); Yang, Kai-Bin^1,2 (AUTHOR); Zhang, Yuan-Zhe^1,2 (AUTHOR)

• Source: Journal of Experimental & Clinical Cancer Research (17569966). 8/31/2024, Vol. 43 Issue 1, p1-20. 20p.

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Embryonic Lethal Phenotyping to Identify Candidate Genes Related with Birth Defects.

• Authors : Yan, Bing¹ (AUTHOR) ; Gong, Baoming¹ (AUTHOR); Zheng, Yufang¹ (AUTHOR)

Subjects: *BODY composition; *HUMAN abnormalities; *LETHAL mutations

• Source: International Journal of Molecular Sciences. Aug2024, Vol. 25 Issue 16, p8788. 14p.

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Mechanisms of lysosomal tubulation and sorting driven by LRRK2.

• Authors : Bonet-Ponce, Luis¹ ; Kluss, Jillian H.²; Cookson, Mark R.³

Subjects: *DARDARIN; *PARKINSON'S disease; *GAIN-of-function mutations

• Source: Biochemical Society Transactions. Aug2024, Vol. 52 Issue 4, p1909-1919. 11p.

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Phages produce persisters.

• Authors : Fernández‐García, Laura^1,2 (AUTHOR); Kirigo, Joy¹ (AUTHOR); Huelgas‐Méndez, Daniel³ (AUTHOR)

Subjects: *KLEBSIELLA pneumoniae; *LETHAL mutations; *GENETIC mutation

• Source: Microbial Biotechnology. Aug2024, Vol. 17 Issue 8, p1-10. 10p.

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Large-scale copy number alterations are enriched for synthetic viability in BRCA1/BRCA2 tumors.

• Authors : Zhu Y; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Subjects: DNA Copy Number Variations* ; BRCA2 Protein*/BRCA2 Protein*/BRCA2 Protein*/genetics ; BRCA1 Protein*/BRCA1 Protein*/BRCA1 Protein*/genetics

• Source: Genome medicine [Genome Med] 2024 Aug 28; Vol. 16 (1), pp. 108. Date of Electronic Publication: 2024 Aug 28.Publisher: BioMed Central Country of Publication: England NLM ID: 101475844 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-994X

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Polθ Inhibitor (ART558) Demonstrates a Synthetic Lethal Effect with PARP and RAD52 Inhibitors in Glioblastoma Cells.

• Authors : Barszczewska-Pietraszek G; Department of Molecular Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland.; Czarny P

Subjects: Glioblastoma*/Glioblastoma*/Glioblastoma*/drug therapy ; Glioblastoma*/Glioblastoma*/Glioblastoma*/pathology ; Glioblastoma*/Glioblastoma*/Glioblastoma*/metabolism

• Source: International journal of molecular sciences [Int J Mol Sci] 2024 Aug 23; Vol. 25 (17). Date of Electronic Publication: 2024 Aug 23.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Synthetic lethality in large-scale integrated metabolic and regulatory network models of human cells.

• Authors : Barrena N; University of Navarra, Tecnun School of Engineering, Manuel de Lardizábal 13, 20018, San Sebastián, Spain.; Valcárcel LV

Subjects: Synthetic Lethal Mutations*/Synthetic Lethal Mutations*/Synthetic Lethal Mutations*/genetics ; Neoplasms*/Neoplasms*/Neoplasms*/genetics ; Neoplasms*/Neoplasms*/Neoplasms*/metabolism

• Source: NPJ systems biology and applications [NPJ Syst Biol Appl] 2023 Jul 15; Vol. 9 (1), pp. 32. Date of Electronic Publication: 2023 Jul 15.Publisher: Nature Publishing Group in partnership with SBI, The Systems Biology Institute Country of Publication: England NLM ID: 101677786 Publication Model:

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