Search Results

Spotlight on amino acid changing mutations in the JAK-STAT pathway: from disease-specific mutation to general mutation databases.

• Authors : Hoffmann M; Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892, USA. .; Hennighausen L

Subjects: STAT Transcription Factors*/STAT Transcription Factors*/STAT Transcription Factors*/genetics ; STAT Transcription Factors*/STAT Transcription Factors*/STAT Transcription Factors*/metabolism ; Signal Transduction*/Signal Transduction*/Signal Transduction*/genetics

• Source: Scientific reports [Sci Rep] 2025 Feb 20; Vol. 15 (1), pp. 6202. Date of Electronic Publication: 2025 Feb 20.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Macrophage invasion into the Drosophila brain requires JAK/STAT-dependent MMP activation in the blood-brain barrier.

• Authors : Winkler B; Institut für Neuro- und Verhaltensbiologie, Universität Münster, Münster, Germany.; Funke D

Subjects: Blood-Brain Barrier*/Blood-Brain Barrier*/Blood-Brain Barrier*/metabolism ; Drosophila melanogaster*/Drosophila melanogaster*/Drosophila melanogaster*/metabolism ; STAT Transcription Factors*/STAT Transcription Factors*/STAT Transcription Factors*/metabolism

• Source: PLoS biology [PLoS Biol] 2025 Feb 20; Vol. 23 (2), pp. e3003035. Date of Electronic Publication: 2025 Feb 20 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet

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Role of Hemocytes in the Aging of Drosophila Male Germline.

• Authors : Varga V; Department of Genetics, Eötvös Loránd University (ELTE), H-1117 Budapest, Hungary.; Doctoral School of Biology, Institute of Biology, ELTE Eötvös Loránd University (ELTE), Pázmány Péter Sétány 1/C, H-1117 Budapest, Hungary.

Subjects: Hemocytes*/Hemocytes*/Hemocytes*/metabolism ; Hemocytes*/Hemocytes*/Hemocytes*/cytology ; Drosophila Proteins*/Drosophila Proteins*/Drosophila Proteins*/metabolism

• Source: Cells [Cells] 2025 Feb 19; Vol. 14 (4). Date of Electronic Publication: 2025 Feb 19.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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IFN-γ-mediated inhibition of JAK/STAT signaling via nano-scutellarin treatment is an efficient strategy for ameliorating liver fibrosis.

• Authors : Wang T; Drug Research Center of Integrated Traditional Chinese and Western Medicine, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Institute of Integrated Chinese and Western Medicine, Southwest Medical University, Luzhou, 646000, Sichuan, China.

Subjects: Interferon-gamma*/Interferon-gamma*/Interferon-gamma*/metabolism ; Signal Transduction*/Signal Transduction*/Signal Transduction*/drug effects ; Liver Cirrhosis*/Liver Cirrhosis*/Liver Cirrhosis*/drug therapy

• Source: Journal of translational medicine [J Transl Med] 2025 Feb 17; Vol. 23 (1), pp. 195. Date of Electronic Publication: 2025 Feb 17.Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876

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MDM2 interacts with PTEN to inhibit endothelial cell development and promote deep vein thrombosis via the JAK/STAT signaling pathway.

• Authors : Jiao J; Department of Vascular Surgery, Fengyang County People's Hospital, Chuzhou, Anhui 233100, P.R. China.; Zhang D

Subjects: PTEN Phosphohydrolase*/PTEN Phosphohydrolase*/PTEN Phosphohydrolase*/metabolism ; PTEN Phosphohydrolase*/PTEN Phosphohydrolase*/PTEN Phosphohydrolase*/genetics ; Venous Thrombosis*/Venous Thrombosis*/Venous Thrombosis*/metabolism

• Source: Molecular medicine reports [Mol Med Rep] 2025 Feb; Vol. 31 (2). Date of Electronic Publication: 2024 Nov 22.Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Elevated LIF and JAK-STAT activation drive severe COVID-19 in myeloma patients receiving the BCMA-CD3 bispecific antibody Elranatamab.

• Authors : Li Z; Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Beijing, 100730, China.; Zhang F

Subjects: Antibodies, Bispecific*/Antibodies, Bispecific*/Antibodies, Bispecific*/therapeutic use ; Multiple Myeloma*/Multiple Myeloma*/Multiple Myeloma*/complications ; Multiple Myeloma*/Multiple Myeloma*/Multiple Myeloma*/immunology

• Source: Journal of translational medicine [J Transl Med] 2025 Jan 26; Vol. 23 (1), pp. 117. Date of Electronic Publication: 2025 Jan 26.Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876

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Anti-Inflammatory Effects of Cannabigerol In Vitro and In Vivo Are Mediated Through the JAK/STAT/NFκB Signaling Pathway.

• Authors : Jeong GH; Department of Medical Sciences, Graduate School of The Catholic University of Korea, Seoul, #222 Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea.; Kim KC

Subjects: NF-kappa B*/NF-kappa B*/NF-kappa B*/metabolism ; Signal Transduction*/Signal Transduction*/Signal Transduction*/drug effects ; Anti-Inflammatory Agents*/Anti-Inflammatory Agents*/Anti-Inflammatory Agents*/pharmacology

• Source: Cells [Cells] 2025 Jan 09; Vol. 14 (2). Date of Electronic Publication: 2025 Jan 09.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Oncogenic STAT Transcription Factors as Targets for Cancer Therapy: Innovative Strategies and Clinical Translation.

• Authors : Wang, Weiyuan¹ (AUTHOR) ; Lopez McDonald, Melanie Cristina¹ (AUTHOR) ; Hariprasad, Rajashree² (AUTHOR)

• Source: Cancers. Apr2024, Vol. 16 Issue 7, p1387. 26p.

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Functional Involvement of Signal Transducers and Activators of Transcription in the Pathogenesis of Influenza A Virus.

• Authors : Liu S; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.; Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

Subjects: Influenza A virus*/Influenza A virus*/Influenza A virus*/physiology ; Signal Transduction* ; STAT Transcription Factors*/STAT Transcription Factors*/STAT Transcription Factors*/metabolism

• Source: International journal of molecular sciences [Int J Mol Sci] 2024 Dec 19; Vol. 25 (24). Date of Electronic Publication: 2024 Dec 19.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Macrophage-like Blood Cells Are Involved in Inter-Tissue Communication to Activate JAK/STAT Signaling, Inducing Antitumor Turandot Proteins in Drosophila Fat Body via the TNF-JNK Pathway.

• Authors : Kinoshita J; Biomedical Research Center, Kyoto Institute of Technology, Matsugasaki, Sakyo, Kyoto 606-0962, Japan.; Graduate School of Science and Technology, Kyoto Institute of Technology, Matsugasaki, Sakyo, Kyoto 606-8585, Japan.

Subjects: Drosophila Proteins*/Drosophila Proteins*/Drosophila Proteins*/metabolism ; Drosophila Proteins*/Drosophila Proteins*/Drosophila Proteins*/genetics ; Hemocytes*/Hemocytes*/Hemocytes*/metabolism

• Source: International journal of molecular sciences [Int J Mol Sci] 2024 Dec 06; Vol. 25 (23). Date of Electronic Publication: 2024 Dec 06.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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