Search Results

Investigation of the effects of benznidazole on the salivary glands: A biochemical, morphological, and functional approach.

• Authors : Lima-da-Silva ECS; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil.; Melo WWP

Subjects: Nitroimidazoles*/Nitroimidazoles*/Nitroimidazoles*/pharmacology ; Salivary Glands*/Salivary Glands*/Salivary Glands*/drug effects ; Salivary Glands*/Salivary Glands*/Salivary Glands*/metabolism

• Source: PloS one [PLoS One] 2025 Jun 03; Vol. 20 (6), pp. e0317876. Date of Electronic Publication: 2025 Jun 03 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Pharmacokinetic-pharmacodynamic modeling of benznidazole and its antitrypanosomal activity in a murine model of chronic Chagas disease.

• Authors : Assmus F; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

Subjects: Nitroimidazoles*/Nitroimidazoles*/Nitroimidazoles*/pharmacokinetics ; Nitroimidazoles*/Nitroimidazoles*/Nitroimidazoles*/administration & dosage ; Nitroimidazoles*/Nitroimidazoles*/Nitroimidazoles*/pharmacology

• Source: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2025 May 13; Vol. 19 (5), pp. e0012968. Date of Electronic Publication: 2025 May 13 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet

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Transcriptomic analysis of benznidazole-resistant Trypanosoma cruzi clone reveals nitroreductase I-independent resistance mechanisms.

• Authors : Mejía-Jaramillo AM; Grupo Biología y Control de Enfermedades Infecciosas, BCEI, Universidad de Antioquia, UdeA, Medellín, Colombia, South America.; Ospina-Zapata H

Subjects: Nitroimidazoles*/Nitroimidazoles*/Nitroimidazoles*/pharmacology ; Trypanosoma cruzi*/Trypanosoma cruzi*/Trypanosoma cruzi*/genetics ; Trypanosoma cruzi*/Trypanosoma cruzi*/Trypanosoma cruzi*/drug effects

• Source: PloS one [PLoS One] 2025 Feb 18; Vol. 20 (2), pp. e0314189. Date of Electronic Publication: 2025 Feb 18 (Print Publication: 2025).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Repurposing the Antidiabetic Drugs Glyburide, Gliquidone, and Glipizide in Combination with Benznidazole for Trypanosoma cruzi Infection.

• Authors : Vázquez C; Department of Biochemistry, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.; Encalada R

• Source: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2024 Dec 27; Vol. 18 (1). Date of Electronic Publication: 2024 Dec 27.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print)

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Effects of Free and Nanoencapsulated Benznidazole in Acute Trypanosoma cruzi Infection: Role of Cholinergic Pathway and Redox Status.

• Authors : da Silva AD; Department of Biochemistry and Molecular Biology, Universidade Federal de Santa Maria, Santa Maria 97105-900, RS, Brazil.; Fracasso M

• Source: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2024 Oct 19; Vol. 17 (10). Date of Electronic Publication: 2024 Oct 19.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print)

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Dissimilar Trypanosoma cruzi genotype-specific serological profile assessed by Chagas-Flow ATE IgG1 upon benznidazole etiological treatment of chronic Chagas disease.

• Authors : Alessio GD; Grupo Integrado de Pesquisas em Biomarcadores, Instituto René Rachou (FIOCRUZ-Minas), Belo Horizonte, Brazil.; Silvestrini CMA

Subjects: Chagas Disease*/Chagas Disease*/Chagas Disease*/drug therapy ; Chagas Disease*/Chagas Disease*/Chagas Disease*/parasitology ; Nitroimidazoles*/Nitroimidazoles*/Nitroimidazoles*/therapeutic use

• Source: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2024 Sep 13; Vol. 18 (9), pp. e0012487. Date of Electronic Publication: 2024 Sep 13 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet

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Benznidazole-Loaded Polymeric Nanoparticles for Oral Chemotherapeutic Treatment of Chagas Disease.

• Authors : Sousa LRD; Laboratório de Fitotecnologia, Programa de Pós-Graduação em Ciências Farmacêuticas, Escola de Farmácia, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, Ouro Preto 35400-000, MG, Brazil.; Duarte THC

• Source: Pharmaceutics [Pharmaceutics] 2024 Jun 13; Vol. 16 (6). Date of Electronic Publication: 2024 Jun 13.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print)

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Chagas Disease: Comparison of Therapy with Nifurtimox and Benznidazole in Indigenous Communities in Colombia.

• Authors : Kann S; Department of Microbiology and Hospital Hygiene, Bundeswehr Central Hospital Koblenz, 56070 Koblenz, Germany.; Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn, 53127 Bonn, Germany.

• Source: Journal of clinical medicine [J Clin Med] 2024 Apr 26; Vol. 13 (9). Date of Electronic Publication: 2024 Apr 26.Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101606588 Publication Model: Electronic Cited Medium: Print ISSN: 2077-0383

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TNF blockers alone and associated with Benznidazole impact in vitro cytokine dynamics in chronic Chagas disease.

• Authors : Torres DJL; Universidade Federal de Pernambuco-UFPE, Recife, Pernambuco, Brazil.; Instituto Aggeu Magalhães-IAM/Fiocruz, Recife, Pernambuco, Brazil.

Subjects: Chagas Disease*/Chagas Disease*/Chagas Disease*/drug therapy ; Heart Diseases*/Heart Diseases*/Heart Diseases*/drug therapy ; Heart Diseases*/Heart Diseases*/Heart Diseases*/parasitology

• Source: Parasite immunology [Parasite Immunol] 2024 Feb; Vol. 46 (2), pp. e13024.Publisher: Wiley Country of Publication: England NLM ID: 7910948 Publication Model: Print Cited Medium: Internet ISSN: 1365-3024 (Electronic)

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Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice.

• Authors : Jayawardhana S; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.; Ward AI

Subjects: Trypanosoma cruzi*/Trypanosoma cruzi*/Trypanosoma cruzi*/genetics ; Nitroimidazoles*/Nitroimidazoles*/Nitroimidazoles*/pharmacology ; Chagas Disease*/Chagas Disease*/Chagas Disease*/parasitology

• Source: PLoS pathogens [PLoS Pathog] 2023 Nov 13; Vol. 19 (11), pp. e1011627. Date of Electronic Publication: 2023 Nov 13 (Print Publication: 2023).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet

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