Search Results

Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model.

• Authors : Tan B; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, NJ 08854, USA.; Zhang X

Subjects: Coronavirus Papain-Like Proteases*/Coronavirus Papain-Like Proteases*/Coronavirus Papain-Like Proteases*/antagonists & inhibitors ; Coronavirus Papain-Like Proteases*/Coronavirus Papain-Like Proteases*/Coronavirus Papain-Like Proteases*/chemistry ; COVID-19* SARS-CoV-2 variants

• Source: Science (New York, N.Y.) [Science] 2024 Mar 29; Vol. 383 (6690), pp. 1434-1440. Date of Electronic Publication: 2024 Mar 28.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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Deubiquitinating activity of SARS-CoV-2 papain-like protease does not influence virus replication or innate immune responses in vivo.

• Authors : van Huizen M; Molecular Virology Laboratory, Leiden University Center of Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, Netherlands.; Bloeme-Ter Horst JR

Subjects: Coronavirus Papain-Like Proteases*/Coronavirus Papain-Like Proteases*/Coronavirus Papain-Like Proteases*/genetics ; COVID-19*; Humans

• Source: PLoS pathogens [PLoS Pathog] 2024 Mar 25; Vol. 20 (3), pp. e1012100. Date of Electronic Publication: 2024 Mar 25 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet

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SARS-CoV-2 sneezing explained.

• Authors : Leslie M

Subjects: COVID-19*/COVID-19*/COVID-19*/physiopathology ; SARS-CoV-2*/SARS-CoV-2*/SARS-CoV-2*/enzymology ; Sneezing*

• Source: Science (New York, N.Y.) [Science] 2024 Jan 26; Vol. 383 (6681), pp. 354. Date of Electronic Publication: 2024 Jan 25.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication in vivo.

• Authors : Taha TY; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, United States of America.; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America.

Subjects: SARS-CoV-2*/SARS-CoV-2*/SARS-CoV-2*/genetics ; SARS-CoV-2*/SARS-CoV-2*/SARS-CoV-2*/physiology ; Virus Replication*

• Source: PLoS pathogens [PLoS Pathog] 2023 Aug 31; Vol. 19 (8), pp. e1011614. Date of Electronic Publication: 2023 Aug 31 (Print Publication: 2023).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet

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A Novel Ambroxol-Derived Tetrahydroquinazoline with a Potency against SARS-CoV-2 Proteins.

• Authors : Krysantieva AI; Institute of Chemistry, University of Tyumen, Volodarskogo Str. 6, 625003 Tyumen, Russia.; Voronina JK

Subjects: Ambroxol*/Ambroxol*/Ambroxol*/analogs & derivatives ; Ambroxol*/Ambroxol*/Ambroxol*/pharmacokinetics ; Ambroxol*/Ambroxol*/Ambroxol*/pharmacology

• Source: International journal of molecular sciences [Int J Mol Sci] 2023 Feb 28; Vol. 24 (5). Date of Electronic Publication: 2023 Feb 28.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Structural Insights into the Interaction of Coronavirus Papain-Like Proteases and Interferon-Stimulated Gene Product 15 from Different Species

• Authors : Pegan, Scott [Univ. of Georgia, Athens, GA (United States)]

• Source: Journal of Molecular Biology; 429; 11

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Hydrogen bonding penalty used for virtual screening to discover potent inhibitors for Papain-Like cysteine proteases of SARS-CoV-2.

• Authors : Zhao G; Key Laboratory of Marine Drugs of Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.; Pilot National Laboratory for Marine Science and Technology, Center for Innovation Marine Drug Screening & Evaluation, Qingdao, China.

Subjects: Antiviral Agents*/Antiviral Agents*/Antiviral Agents*/chemistry ; Antiviral Agents*/Antiviral Agents*/Antiviral Agents*/pharmacology ; Coronavirus Papain-Like Proteases*/Coronavirus Papain-Like Proteases*/Coronavirus Papain-Like Proteases*/antagonists & inhibitors

• Source: Chemical biology & drug design [Chem Biol Drug Des] 2022 Oct; Vol. 100 (4), pp. 502-514. Date of Electronic Publication: 2022 Jul 26.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101262549 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Evaluating Stability and Activity of SARS-CoV-2 PLpro for High-throughput Screening of Inhibitors.

• Authors : Arya R; Protein Crystallography Section, Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, 400085, India.; Homi Bhabha National Institute, Anushakti Nagar, Mumbai, 400094, India.

Subjects: Coronavirus Papain-Like Proteases/Coronavirus Papain-Like Proteases/Coronavirus Papain-Like Proteases/*chemistry ; Coronavirus Papain-Like Proteases/Coronavirus Papain-Like Proteases/Coronavirus Papain-Like Proteases/*metabolism ; High-Throughput Screening Assays/High-Throughput Screening Assays/High-Throughput Screening Assays/*methods

• Source: Molecular biotechnology [Mol Biotechnol] 2022 Jan; Vol. 64 (1), pp. 1-8. Date of Electronic Publication: 2021 Aug 22.Publisher: Springer Country of Publication: Switzerland NLM ID: 9423533 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Isolation and In Silico Anti-SARS-CoV-2 Papain-Like Protease Potentialities of Two Rare 2-Phenoxychromone Derivatives from Artemisia spp.

• Authors : Suleimen YM; The International Centre for Interdisciplinary Solutions on Antibiotics and Secondary Metabolites, Republican Collection of Microorganisms, Nur-Sultan 010000, Kazakhstan.; The Laboratory of Engineering Profile of NMR Spectroscopy, Sh. Ualikhanov Kokshetau University, Kokshetau 020000, Kazakhstan.

Subjects: Coronavirus Papain-Like Proteases*/Coronavirus Papain-Like Proteases*/Coronavirus Papain-Like Proteases*/antagonists & inhibitors ; Coronavirus Papain-Like Proteases*/Coronavirus Papain-Like Proteases*/Coronavirus Papain-Like Proteases*/chemistry; Artemisia/Artemisia/Artemisia/*chemistry

• Source: Molecules (Basel, Switzerland) [Molecules] 2022 Feb 11; Vol. 27 (4). Date of Electronic Publication: 2022 Feb 11.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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In silico analysis of SARS-CoV-2 proteins as targets for clinically available drugs.

• Authors : Chan WKB; Department of Pharmacology, University of Michigan, 2301 MSRBIII, 1150 W Medical Center Dr, Ann Arbor, MI, 48190-5606, USA.; Edward F Domino Research Center, University of Michigan, Ann Arbor, MI, 48190, USA.

Subjects: Coronavirus Papain-Like Proteases*/Coronavirus Papain-Like Proteases*/Coronavirus Papain-Like Proteases*/antagonists & inhibitors ; Nucleocapsid Proteins*/Nucleocapsid Proteins*/Nucleocapsid Proteins*/antagonists & inhibitors ; SARS-CoV-2*/SARS-CoV-2*/SARS-CoV-2*/drug effects

• Source: Scientific reports [Sci Rep] 2022 Mar 29; Vol. 12 (1), pp. 5320. Date of Electronic Publication: 2022 Mar 29.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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